PainReform

PainReform

PRFX
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PRFX · Stock Price

USD 1.90-7.40 (-79.57%)
Market Cap: $1.7M

Historical price data

Market Cap: $1.7MPipeline: 4 drugs (1 Phase 3)HQ: Israel

Overview

PainReform's mission is to transform post-operative care by developing proprietary, extended-release formulations of established therapeutics to reduce opioid reliance. Its core achievement is the advancement of PRF-110 into Phase 3 for bunionectomy pain, with positive Phase 2 data in hernia repair. The company's strategy leverages a lower-risk reformulation approach to create new intellectual property and has recently expanded its scope to include AI for solar energy optimization under the new PRF Technologies umbrella.

Pain ManagementOphthalmology

Technology Platform

Proprietary platform for creating sustained-release formulations of established drugs, utilizing polymer-based and oil-based delivery systems for localized, extended therapeutic effect.

Pipeline

4
4 drugs in pipeline1 in Phase 3
DrugIndicationStageWatch
RopivacaineBunionPhase 3
PRF110- oily solution (Ropivacaine)Post Operative PainPhase 2
PRF110Post Operative PainPhase 2
PRF-108 + Placebo + Ropivacaine + PRF-110PainPhase 1/2

Opportunities

A successful Phase 3 readout for PRF-110 could unlock a multi-billion dollar non-opioid pain market and attract partnership interest.
The DeepSolar platform offers potential for non-dilutive revenue diversification in the high-growth renewable energy sector.

Risk Factors

The company faces binary clinical risk with its lead asset, PRF-110, and has a limited cash runway.
The recent strategic diversification into energy analytics introduces execution risk and may divert focus from core drug development.

Competitive Landscape

PRF-110 competes in the long-acting local anesthetic market against established products like Exparel (Pacira). The company's reformulation strategy is common, requiring superior clinical data to gain market share. Its dual biotech/energy tech model lacks clear peers.