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Oragenics

Oragenics

OGEN
United States
oragenics.com
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OGEN · Stock Price

USD 0.61-4.49 (-88.04%)
Market Cap: $2.7M

Historical price data

Overview

Oragenics is a development-stage biotech focused on transforming treatment paradigms for neurological and infectious diseases through its proprietary intranasal delivery technology. Its core mission is to enable 'brain-first recovery' by bypassing the blood-brain barrier for direct CNS delivery of therapeutics. Key achievements include the completion of a Phase I safety study for its lead neurosteroid, ONP-002, for concussion, and the advancement of an intranasal COVID-19 vaccine candidate. The company's strategy leverages its platform to pursue high-need, underserved markets with non-invasive, targeted therapies.

NeurologyInfectious Disease

Technology Platform

Proprietary intranasal delivery platform utilizing spray-dried nanoparticles to bypass the blood-brain barrier, combined with novel enantiomeric-neurosteroid chemistry for targeted CNS therapeutics.

Pipeline

2
2 drugs in pipeline
DrugIndicationStageWatch
Neurosteroid enantiomerMild Traumatic Brain Injury, ConcussionPhase 2
AG013Oral MucositisPhase 2

Funding History

1
Total raised:$10M
IPO$10M

Opportunities

ONP-002 targets a vast, untreated market for concussion with first-mover potential.
The intranasal platform could be leveraged across multiple CNS disorders, and the vaccine program addresses the need for needle-free, mucosally-administered vaccines with easier distribution.

Risk Factors

High risk of clinical failure for lead asset ONP-002; severe financial risk with a going concern qualification requiring immediate and dilutive financing; intense competition in both neurology and vaccine spaces.

Competitive Landscape

Faces limited direct competition in concussion pharmacotherapy but broader competition in intranasal CNS delivery and intranasal vaccines. Differentiation hinges on the unique neurosteroid chemistry combined with targeted delivery.

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