Oncolytics Biotech
ONCYONCY · Stock Price
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Overview
Oncolytics Biotech is singularly focused on developing its first-in-class, intravenously delivered oncolytic reovirus, pelareorep, as a platform immunotherapy for gastrointestinal (GI) tumors. The company has generated compelling clinical data across multiple GI cancers, including metastatic pancreatic ductal adenocarcinoma (mPDAC), KRAS-mutant metastatic colorectal cancer (mCRC), and squamous cell carcinoma of the anus (SCAC), demonstrating survival benefits that significantly exceed historical benchmarks. Its strategy is to advance these programs into registration-focused studies, leveraging Fast Track Designation in pancreatic and colorectal cancer to potentially accelerate the path to market.
Technology Platform
Pelareorep is a first-in-class, systemically delivered oncolytic reovirus that selectively replicates in RAS-activated tumor cells, inducing immunogenic cell death and priming a potent, durable anti-tumor immune response to convert 'cold' tumors to 'hot'.
Pipeline
20| Drug | Indication | Stage | Watch |
|---|---|---|---|
| REOLYSIN + Carboplatin + Paclitaxel + Placebo | Carcinoma, Squamous Cell of the Head and Neck | Phase 3 | |
| Bevacizumab + FOLFIRI + Pelareorep | Ras-mutated Metastatic Colorectal Cancer | Phase 2 | |
| Pemetrexed and Reolysin (and safety run-in) + Pemetrexed + D... | Non Small Cell Lung Cancer | Phase 2 | |
| REOLYSIN + Carboplatin + Paclitaxel | Metastatic Melanoma | Phase 2 | |
| REOLYSIN® + Carboplatin + Paclitaxel | Carcinoma, Non-small Cell Lung | Phase 2 |