OSE Immunotherapeutics

OSE Immunotherapeutics

OSE.PA
Nantes, France· Est.
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OSE.PA · Stock Price

EUR 3.94-2.03 (-34.00%)
Market Cap: $106.9M

Historical price data

Market Cap: $106.9MPipeline: 10 drugs (2 Phase 3)Founded: 2012HQ: Nantes, France

Overview

OSE Immunotherapeutics is an integrated, clinical-stage biotechnology company focused on developing first-in-class immunotherapies for immuno-oncology and immuno-inflammation. Its core strategy is driven by three proprietary technology platforms designed to precisely modulate the immune system. The company's most significant near-term catalyst is the Phase 3 ARTEMIA trial for Tedopi® in non-small cell lung cancer, which has received two positive IDMC recommendations. OSE aims to build value through a diversified pipeline and strategic partnerships.

OncologyAutoimmune DiseasesInflammation

Technology Platform

Three proprietary platforms: 1) T-cell activation via neo-epitopes for cancer vaccines, 2) Reprogramming of immunosuppressive tumor microenvironment cells, and 3) Dual modulation of T-effector and regulatory T-cells for immune tolerance in autoimmunity.

Pipeline

10
10 drugs in pipeline2 in Phase 3
DrugIndicationStageWatch
OSE2101 + DocetaxelPatients With Non-Small Cell Lung CancerPhase 3
OSE2101 + Docetaxel + PemetrexedNon Small Cell Lung CancerPhase 3
OSE-127 + PlaceboUlcerative ColitisPhase 2
FOLFIRI + OSE2101Pancreatic Ductal AdenocarcinomaPhase 2
FR104Kidney TransplantationPhase 1/2

Funding History

3
Total raised:$45M
Grant$10M
PIPE$20M
IPO$15M

Opportunities

The primary opportunity is the large, underserved market of NSCLC patients who have failed checkpoint inhibitor therapy, where Tedopi® could become a new standard.
Additionally, validating its immuno-inflammation platform through the partnered OSE-127 program in ulcerative colitis and Sjögren's could unlock significant non-dilutive value and prove the broader applicability of its science.

Risk Factors

The dominant risk is clinical failure of the pivotal Phase 3 ARTEMIA trial for Tedopi®, which would severely impact the company's value.
Additional key risks include limited financial runway requiring dilutive financing, intense competition in all target indications, and potential challenges in commercializing an approved product independently.

Competitive Landscape

OSE faces intense competition from large pharma and biotech across its focus areas. In post-checkpoint NSCLC, Tedopi® must compete against chemotherapies and a pipeline of novel agents. In autoimmunity, OSE-127 enters crowded markets dominated by established biologics. Its platforms compete with well-funded rivals in bispecific antibodies and novel checkpoint inhibition.

Company Timeline

2012Founded

Founded in Nantes, France

2015IPO

IPO — $15.0M

2018PIPE

PIPE: $20.0M

2020Grant

Grant: $10.0M