enGene

enGene

ENGNPhase 2

enGene is a Canadian biotech focused on creating a new class of genetic medicines using its proprietary non-viral gene delivery platform. The company's lead program, EG-70, is in clinical development for non-muscle invasive bladder cancer (NMIBC), aiming to overcome the limitations of current viral vector-based therapies. enGene leverages its platform to target mucosal tissues with high efficiency and localized effect, potentially addressing a range of diseases. The company went public in 2023 to fund its clinical advancement and platform expansion.

Market Cap
$483.0M
Employees
50-100
Focus
Biotech

ENGN · Stock Price

USD 7.212.72 (-27.39%)

Historical price data

AI Company Overview

enGene is a Canadian biotech focused on creating a new class of genetic medicines using its proprietary non-viral gene delivery platform. The company's lead program, EG-70, is in clinical development for non-muscle invasive bladder cancer (NMIBC), aiming to overcome the limitations of current viral vector-based therapies. enGene leverages its platform to target mucosal tissues with high efficiency and localized effect, potentially addressing a range of diseases. The company went public in 2023 to fund its clinical advancement and platform expansion.

Technology Platform

Proprietary non-viral gene delivery platform using engineered dextran-derived complexes (DDX) for localized, efficient transfection of mucosal tissues.

Pipeline Snapshot

1

1 drug in pipeline

DrugIndicationStage
EG-70 (phase 1) + EG-70 (phase 2)Superficial Bladder CancerPhase 1/2

Funding History

4

Total raised: $370M

IPO$90MUndisclosedNov 9, 2023
Series C$200MFrazier Life SciencesOct 15, 2022
Series B$65MForbionDec 15, 2020
Series A$15MFonds de solidarité FTQJun 15, 2018

Opportunities

The primary opportunity is addressing the high-unmet need in BCG-unresponsive bladder cancer with a novel, localized therapy.
Long-term, the platform offers potential expansion into large markets for gastrointestinal and pulmonary diseases, representing a multi-billion dollar pipeline opportunity.

Risk Factors

Key risks include clinical trial failure of the lead candidate EG-70, regulatory hurdles for a novel gene therapy, intense competition in the bladder cancer space, and challenges in scaling manufacturing.
As a pre-revenue company, it also faces financial risk and dependence on capital markets.

Competitive Landscape

Main competitors in NMIBC include Merck's Keytruda and Ferring's Adstiladrin. enGene differentiates through its non-viral, localized delivery platform, which may offer improved safety and repeat dosing potential compared to viral gene therapies and systemic immunotherapies.

Publications
11
Patents
10
Pipeline
1

Company Info

TypeTherapeutics
Founded2010
Employees50-100
LocationMontreal, Canada
StagePhase 2
RevenuePre-revenue

Trading

TickerENGN
ExchangeNASDAQ

Contact

Therapeutic Areas

OncologyInflammatory DiseasesGenetic Disorders
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