Can Fite Biopharma

Can Fite Biopharma

CANF
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CANF · Stock Price

USD 3.54-18.66 (-84.05%)
Market Cap: $7.4M

Historical price data

Market Cap: $7.4MPipeline: 22 drugs (6 Phase 3)Founded: 1994HQ: Petah Tikva, Israel

Overview

Can Fite Biopharma's mission is to develop and commercialize novel, orally available therapeutics targeting the A3 adenosine receptor for oncology, inflammatory, and metabolic diseases. Its key achievements include establishing a robust pipeline with multiple Phase II/III candidates, securing significant out-licensing partnerships for its lead assets across major markets in Asia, Europe, and North America, and generating clinical proof-of-concept for its platform. The company's strategy is to advance its most promising programs through late-stage trials to achieve regulatory milestones, while continuing to monetize its pipeline through regional partnerships and non-dilutive funding to drive towards commercialization.

OncologyInflammatory DiseasesMetabolic Diseases

Technology Platform

Platform of orally bioavailable small molecule agonists targeting the A3 adenosine receptor (A3AR), which is overexpressed in pathological cells, to induce apoptosis in cancer cells and modulate immune response in inflammatory diseases.

Pipeline

22
22 drugs in pipeline6 in Phase 3
DrugIndicationStageWatch
CF101Keratoconjunctivitis SiccaPhase 3
Namodenoson + PlaceboHepatocellular CarcinomaPhase 3
piclidenoson + PlaceboPlaque PsoriasisPhase 3
CF101 1 mg + CF101 2 mg + Placebo + MTXRheumatoid ArthritisPhase 3
CF101 2mg + CF101 3mg + Apremilast 30mg + Placebo Oral Table...Plaque PsoriasisPhase 3

Funding History

4
Total raised:$23.5M
PIPE$7.5M
PIPE$5M
IPO$8M
Seed$3M

Opportunities

Lead drug Piclidenoson addresses a multi-billion dollar psoriasis market with a novel oral mechanism, offering convenience over injectable biologics.
Namodenoson targets high-need niches in liver cancer (Child-Pugh B patients) and the massive, untapped NASH market, where positive data could drive significant partnership or acquisition interest.

Risk Factors

High risk of clinical failure in ongoing late-stage trials for psoriasis and liver cancer, which could erase significant value.
The company's low market cap and pre-revenue status necessitate continual capital raises, posing dilution risk, and it faces intense competition in all its therapeutic areas from large pharma and biotech players.

Competitive Landscape

Faces entrenched competition in psoriasis from biologic and oral JAK inhibitors, in liver cancer from TKIs and immunotherapies, and in NASH from a crowded field of late-stage candidates. Its primary differentiation is the novel A3AR target, but it must demonstrate clear efficacy and safety advantages to secure market share.

Company Timeline

1994Founded

Founded in Petah Tikva, Israel

2015IPO

IPO — $8.0M

2019PIPE

PIPE: $5.0M

2021PIPE

PIPE: $7.5M