Iptacopan

Pre-clinicalActive

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Interest: 30/100

Hype Score

Development Stage

Pre-clinical

Phase 1

Phase 2

Phase 3

Approved

Indication / Disease

Hemoglobinuria, Paroxysmal

Conditions

Hemoglobinuria, Paroxysmal

Trial Timeline

Mar 31, 2025 → Oct 1, 2029

NCT ID

NCT06903234

About Iptacopan

Iptacopan is a pre-clinical stage product being developed by Novartis for Hemoglobinuria, Paroxysmal. The current trial status is active. This product is registered under clinical trial identifier NCT06903234. Target conditions include Hemoglobinuria, Paroxysmal.

What happened to similar drugs?

0 of 18 similar drugs in Hemoglobinuria, Paroxysmal were approved

Approved (0) Terminated (2) Active (16)

🔄Crovalimab + EculizumabChugai PharmaceuticalPhase 3

🔄EculizumabAstraZenecaPhase 3

🔄DanicopanAstraZenecaPhase 3

🔄Iptacopan (LNP023)NovartisPhase 3

🔄IptacopanNovartisPhase 3

🔄LNP023 + Eculizumab + RavulizumabNovartisPhase 3

Hype Score Breakdown

Clinical

Activity

Company

Novelty

Community

Clinical Trials (11)

NCT ID	Phase	Status	Start	Completion	Indication
NCT05222412	Pre-clinical	Active	—	—	C3 Glomerulopathy (C3G)
NCT06994845	Phase 3	Recruiting	Nov 27, 2025	Jun 30, 2030	Primary Immunoglobulin A Nephropathy (IgAN)
NCT06903234	Pre-clinical	Active	Mar 31, 2025	Oct 1, 2029	Hemoglobinuria, Paroxysmal
NCT06797518	Phase 2	Recruiting	Feb 21, 2025	Nov 27, 2027	Glomerulonephritis, IGA
NCT06517758	Phase 3	Recruiting	Jul 31, 2024	May 27, 2032	Generalized Myasthenia Gravis
NCT05935215	Phase 3	Recruiting	Feb 28, 2024	Jul 19, 2029	Atypical Hemolytic Uremic Syndrome
NCT05630001	Phase 3	Completed	Apr 24, 2023	Oct 17, 2024	Paroxysmal Nocturnal Hemoglobinuria
NCT04889430	Phase 3	Active	Jan 17, 2022	Aug 13, 2026	Atypical Hemolytic Uremic Syndrome
NCT05086744	Phase 2	Terminated	Dec 21, 2021	May 17, 2024	Immune Thrombocytopenia (ITP)
NCT04747613	Phase 3	Active	Jul 27, 2021	Oct 19, 2027	Paroxysmal Nocturnal Hemoglobinuria
NCT03439839	Phase 2	Completed	Apr 9, 2018	Feb 28, 2022	Paroxysmal Nocturnal Hemoglobinuria (PNH) With Signs of Active Hemolysis

Competing Products

20 competing products in Hemoglobinuria, Paroxysmal

See all competitors

Product	Company	Stage	Hype Score
Crovalimab + Eculizumab	Chugai Pharmaceutical	Phase 3	44
Crovalimab + Placebo	Chugai Pharmaceutical	Phase 1/2	36
Crovalimab + Eculizumab	Chugai Pharmaceutical	Phase 3	44
Eculizumab	AstraZeneca	Phase 3	40
Danicopan	AstraZeneca	Phase 3	47
LNP023	Novartis	Pre-clinical	33
Iptacopan (LNP023)	Novartis	Phase 3	40
iptacopan	Novartis	Phase 2	35
LNP023	Novartis	Phase 2	35
Iptacopan	Novartis	Phase 3	40
LNP023 + Eculizumab + Ravulizumab	Novartis	Phase 3	40
LNP023	Novartis	Phase 3	47
LFG316 + LNP023	Novartis	Phase 2	35
Iptacopan	Novartis	Phase 3	44
Crovalimab	Roche	Phase 3	44
ABP 959 + Eculizumab	Amgen	Phase 3	40
Pegcetacoplan	Swedish Orphan Biovitrum	Pre-clinical	33
Humanized anti-Factor Bb monoclonal antibody + Placebo	Sanofi	Phase 1	29
REGN3918	Regeneron Pharmaceuticals	Phase 2	35
Pozelimab + Cemdisiran	Regeneron Pharmaceuticals	Phase 2	35