Humanized anti-Factor Bb monoclonal antibody + Placebo

Phase 1Completed

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Interest: 29/100

Hype Score

Development Stage

✓

Pre-clinical

Phase 1

Phase 2

Phase 3

Approved

Indication / Disease

Paroxysmal Nocturnal Hemoglobinuria

Conditions

Paroxysmal Nocturnal Hemoglobinuria

Trial Timeline

Oct 11, 2021 → May 5, 2023

NCT ID

NCT06326814

About Humanized anti-Factor Bb monoclonal antibody + Placebo

Humanized anti-Factor Bb monoclonal antibody + Placebo is a phase 1 stage product being developed by Sanofi for Paroxysmal Nocturnal Hemoglobinuria. The current trial status is completed. This product is registered under clinical trial identifier NCT06326814. Target conditions include Paroxysmal Nocturnal Hemoglobinuria.

What happened to similar drugs?

0 of 20 similar drugs in Paroxysmal Nocturnal Hemoglobinuria were approved

Approved (0) Terminated (4) Active (16)

🔄Crovalimab + EculizumabChugai PharmaceuticalPhase 3

🔄EculizumabAstraZenecaPhase 3

🔄DanicopanAstraZenecaPhase 3

🔄Iptacopan (LNP023)NovartisPhase 3

🔄IptacopanNovartisPhase 3

🔄LNP023 + Eculizumab + RavulizumabNovartisPhase 3

Hype Score Breakdown

Clinical

Activity

Company

Novelty

Community

Clinical Trials (1)

NCT ID	Phase	Status	Start	Completion	Indication
NCT06326814	Phase 1	Completed	Oct 11, 2021	May 5, 2023	Paroxysmal Nocturnal Hemoglobinuria

Competing Products

20 competing products in Paroxysmal Nocturnal Hemoglobinuria

See all competitors

Product	Company	Stage	Hype Score
Crovalimab + Eculizumab	Chugai Pharmaceutical	Phase 3	44
Crovalimab + Placebo	Chugai Pharmaceutical	Phase 1/2	36
Crovalimab + Eculizumab	Chugai Pharmaceutical	Phase 3	44
Ravulizumab	AstraZeneca	Pre-clinical	30
Eculizumab	AstraZeneca	Phase 3	40
Danicopan	AstraZeneca	Phase 3	47
LNP023	Novartis	Pre-clinical	33
Iptacopan (LNP023)	Novartis	Phase 3	40
iptacopan	Novartis	Phase 2	35
LNP023	Novartis	Phase 2	35
Iptacopan	Novartis	Pre-clinical	30
Iptacopan	Novartis	Phase 3	40
LNP023 + Eculizumab + Ravulizumab	Novartis	Phase 3	40
LNP023	Novartis	Phase 3	47
LFG316 + LNP023	Novartis	Phase 2	35
Iptacopan	Novartis	Phase 3	44
Crovalimab	Roche	Phase 3	44
ABP 959 + Eculizumab	Amgen	Phase 3	40
Pegcetacoplan	Swedish Orphan Biovitrum	Pre-clinical	33
BMS-919373 + Placebo (Matching with BMS-919373)	Bristol Myers Squibb	Phase 2	27