PEGylated Pirfenidone
Heart Failure with Preserved Ejection Fraction (HFpEF)
Pre-clinicalActive
Key Facts
Indication
Heart Failure with Preserved Ejection Fraction (HFpEF)
Phase
Pre-clinical
Status
Active
Company
About i-Cordis
i-Cordis is a private, preclinical biotech focused on revolutionizing the treatment of heart failure with preserved ejection fraction (HFpEF) through immunomodulation. The company's lead asset is a PEGylated derivative of pirfenidone, designed to overcome the original drug's limitations (e.g., frequent dosing, CNS side effects) while enhancing cardioprotective effects. With a strong scientific foundation based on the Phase II PIROUETTE trial data for pirfenidone in HFpEF and a world-class team of cardiac immunology experts, i-Cordis is positioning its novel compound as a potential first-in-class therapy for a large, underserved patient population.
View full company profileTherapeutic Areas
Other Heart Failure with Preserved Ejection Fraction (HFpEF) Drugs
| Drug | Company | Phase |
|---|---|---|
| Barostim™ | CVRx | Clinical Feasibility |
| MANP | E-Star BioTech | Phase 1/2 |
| ALLAY-HF | Alleviant Medical | Pivotal Trial |
| VS-041 | Vasa Therapeutics | Phase 1 |
| Neucardin® | Zensun Sci & Tech | Phase 2 |
| SAVM Procedure | Axon Therapies | Phase 2 |
| SRD001 (inferred) | Sardocor | Phase 1 |
| STM-01 | Secretome Therapeutics | Phase 1 |