CG Oncology

CG Oncology

CGONPhase 3
Irvine, United StatesFounded 2010cgoncology.com

CG Oncology is a publicly traded, late-stage biopharma company singularly dedicated to transforming the treatment landscape for bladder cancer patients. Its core asset, cretostimogene grenadenorepvec, is an engineered oncolytic immunotherapy with a dual mechanism of action designed to selectively destroy cancer cells and stimulate a systemic anti-tumor immune response. The company is advancing this candidate through a pivotal Phase 3 program (PIVOT-006) for BCG-unresponsive NMIBC, with the goal of establishing it as a new backbone, bladder-sparing therapeutic. Backed by experienced leadership and investors, CG Oncology is positioned as a potential leader in urologic oncology.

Market Cap
$5.5B
Founded
2010
Focus
BiologicsViral Technology

CGON · Stock Price

USD 65.08+27.91 (+75.09%)

Historical price data

AI Company Overview

CG Oncology is a publicly traded, late-stage biopharma company singularly dedicated to transforming the treatment landscape for bladder cancer patients. Its core asset, cretostimogene grenadenorepvec, is an engineered oncolytic immunotherapy with a dual mechanism of action designed to selectively destroy cancer cells and stimulate a systemic anti-tumor immune response. The company is advancing this candidate through a pivotal Phase 3 program (PIVOT-006) for BCG-unresponsive NMIBC, with the goal of establishing it as a new backbone, bladder-sparing therapeutic. Backed by experienced leadership and investors, CG Oncology is positioned as a potential leader in urologic oncology.

Technology Platform

Engineered oncolytic immunotherapy platform based on an intravesically delivered adenovirus designed for selective replication in cancer cells and stimulation of a systemic anti-tumor immune response.

Pipeline Snapshot

8

8 drugs in pipeline, 3 in Phase 3

DrugIndicationStageWatch
Cretostimogene GrenadenorepvecNon Muscle Invasive Bladder CancerPhase 3
Cretostimogene GrenadenorepvecNon Muscle Invasive Bladder CancerPhase 3
CG0070 Adenovirus VectorTransitional Cell CarcinomaPhase 2/3
CG0070Bladder CancerPhase 2
oncolytic adenovirus expressing GMCSFBladder CancerPhase 2

Funding History

5

Total raised: $618M

IPO$380MUndisclosedJan 25, 2024
Series D$105MKite PharmaJun 15, 2022
Series C$75MDecheng CapitalJun 15, 2020
Series B$43MTakeda VenturesJun 15, 2018

Opportunities

The primary opportunity is successfully launching cretostimogene as the new backbone therapy for BCG-unresponsive NMIBC, capturing a large market with high unmet need.
Further opportunities include expanding into earlier lines of NMIBC treatment (e.g., BCG-naïve), exploring combination regimens with other immunotherapies, and potentially applying the oncolytic immunotherapy platform to other localized cancers.

Risk Factors

The company faces binary clinical risk from its pivotal Phase 3 trial, regulatory approval risk, and commercialization risk as a new entrant competing against established therapies.
It also carries significant concentration risk with its entire value dependent on a single asset.

Competitive Landscape

Main competitors include approved therapies for BCG-unresponsive NMIBC like nadofaragene firadenovec (Adstiladrin) and pembrolizumab (Keytruda). CG Oncology differentiates with cretostimogene's oncolytic immunotherapy mechanism, designed for direct tumor lysis and immune activation via intravesical delivery, positioning it as a potential backbone treatment with a favorable tolerability profile.

Publications
5
Patents
5
Pipeline
8

Company Info

TypeTherapeutics
Founded2010
LocationIrvine, United States
StagePhase 3
RevenuePre-revenue

Trading

TickerCGON
ExchangeNASDAQ

Therapeutic Areas

OncologyUrologic Oncology

Partners

SUO-CTC (Society of Urologic Oncology Clinical Trials Consortium) - announced collaboration for NMIBC conference
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