ImmunityBio

ImmunityBio

IBRX
United States· Est.
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IBRX · Stock Price

USD 7.76+5.69 (+274.88%)
Market Cap: $8.1B

Historical price data

Overview

ImmunityBio is a clinical-stage biotech focused on developing a 'Cancer BioShield' through its proprietary immunotherapy platforms, including the IL-15 superagonist ANKTIVA® and off-the-shelf NK cell therapies. The company's core mission is to defeat cancer and infectious diseases by enhancing, rather than weakening, the patient's immune system. Its first FDA approval in 2024 for bladder cancer validates its scientific approach and provides a commercial foundation for expanding into multiple solid tumor and infectious disease indications.

Bladder CancerNon-Small Cell Lung CancerGlioblastomaLynch SyndromeNon-Hodgkin LymphomaOvarian CancerHIV

Technology Platform

Integrated 'triangle offense' immunotherapy platform featuring the first-in-class IL-15 superagonist ANKTIVA® to stimulate NK and T cells, combined with off-the-shelf activated NK (aNK) cell therapies and next-generation adenoviral cancer vaccines.

Pipeline

81
81 drugs in pipeline5 in Phase 3
DrugIndicationStageWatch
NAI + Pembrolizumab + NAI + Nivolumab + Ipilimumab + Pembrol...Non Small Cell Lung CancerPhase 3
N-803 + Tislelizumab + DocetaxelNSCLC Stage IVPhase 3
Aldoxorubicin + Investigator's Choice Treatment (Darcabazine...Metastatic, Locally Advanced or Unresectable Soft Tissue SarcomaPhase 3
N-803 and BCG + N-803Bladder CancerPhase 2/3
hAd5-S-Fusion+N-ETSD + Placebo (0.9% (w/v) saline)COVID-19Phase 2/3

FDA Approved Drugs

1
ANKTIVABLAApr 22, 2024

Opportunities

Substantial market expansion through approval in BCG-naïve bladder cancer and checkpoint inhibitor-refractory NSCLC, two large oncology segments.
Global regulatory approvals (e.g., Saudi Arabia, Macau) provide ex-U.S.
growth vectors.
The modular platform offers broad combination potential across oncology and infectious diseases.

Risk Factors

Commercial execution risk with first product launch; clinical and regulatory setbacks in late-stage pipeline trials; ongoing cash burn and future capital needs despite recent non-dilutive financing; intense competition in immunotherapy and cell therapy markets.

Competitive Landscape

Faces competition in IL-15 space from several clinical-stage biotechs, in bladder cancer from checkpoint inhibitors and gene therapies, and in NK cell therapy from multiple allogeneic platforms. Its differentiated 'triangle offense' strategy aims to synergize with, rather than directly replace, existing modalities.