ImmunityBio

ImmunityBio

IBRXApproved
Founded 2014immunitybio.com

ImmunityBio, founded in 2014 by Dr. Patrick Soon-Shiong, is pioneering immunotherapy 2.0 with a 'triangle offense' approach that simultaneously activates NK cells, T cells, and other immune effectors. The company achieved a major milestone with FDA approval of ANKTIVA® for bladder cancer in April 2024, demonstrating 71% complete response rates and over 90% bladder preservation. With 18 trials in Phase 2 or 3 development and expanding global presence through recent approvals in Europe, Saudi Arabia, and Macau, ImmunityBio is positioned as a leader in the next generation of cancer immunotherapy. The company's platforms address multiple solid tumors and infectious diseases including HIV, representing significant market opportunities beyond their initial bladder cancer indication.

Market Cap
$8.7B
Founded
2014
Focus
Cell & Gene Therapy

IBRX · Stock Price

USD 8.47+2.73 (+47.56%)

Historical price data

AI Company Overview

ImmunityBio, founded in 2014 by Dr. Patrick Soon-Shiong, is pioneering immunotherapy 2.0 with a 'triangle offense' approach that simultaneously activates NK cells, T cells, and other immune effectors. The company achieved a major milestone with FDA approval of ANKTIVA® for bladder cancer in April 2024, demonstrating 71% complete response rates and over 90% bladder preservation. With 18 trials in Phase 2 or 3 development and expanding global presence through recent approvals in Europe, Saudi Arabia, and Macau, ImmunityBio is positioned as a leader in the next generation of cancer immunotherapy. The company's platforms address multiple solid tumors and infectious diseases including HIV, representing significant market opportunities beyond their initial bladder cancer indication.

Technology Platform

Multi-modal immunotherapy platform featuring ANKTIVA® (IL-15 superagonist), activated NK cell therapies, and adenoviral cancer vaccines designed to create a 'triangle offense' activating both innate and adaptive immune responses while preserving immune system integrity.

Pipeline Snapshot

81

81 drugs in pipeline, 5 in Phase 3

DrugIndicationStage
Aldoxorubicin + Investigator's Choice Treatment (Darcabazine, Pazopanib, Gemcita...Metastatic, Locally Advanced or Unresectable Soft Tissue SarcomaPhase 3
N-803 + Tislelizumab + DocetaxelNSCLC Stage IVPhase 3
NAI + Pembrolizumab + NAI + Nivolumab + Ipilimumab + Pembrolizumab + NAI + Pembr...Non Small Cell Lung CancerPhase 3
hAd5-S-Fusion+N-ETSD + Placebo (0.9% (w/v) saline)COVID-19Phase 2/3
N-803 and BCG + N-803Bladder CancerPhase 2/3

FDA Approved Drugs

1
ANKTIVABLAApr 22, 2024

Opportunities

Significant expansion opportunities through ANKTIVA® approval in multiple new indications across the robust Phase 2/3 pipeline, international market expansion following recent regulatory approvals in Europe and Asia, and platform leverage across the extensive NK cell and combination therapy programs targeting high unmet need markets.

Risk Factors

Clinical trial execution risks across the extensive 27-trial pipeline, manufacturing scale-up challenges for complex cell therapies, intense competition in the crowded immunotherapy market, and regulatory approval uncertainties for new indications beyond the initial bladder cancer approval.

Competitive Landscape

ImmunityBio differentiates in the competitive immunotherapy space through its first-in-class IL-15 agonist platform, multi-modal triangle offense approach, and proven clinical efficacy with 71% complete response rates in bladder cancer. Main competitors include checkpoint inhibitor leaders like Bristol Myers Squibb and Merck, CAR-T companies like Gilead Sciences, and emerging immunotherapy platforms, though ImmunityBio's unique mechanism and clinical validation provide competitive advantages.

Publications
20
Patents
20
Pipeline
81
FDA Approvals
1

Company Info

TypeTherapeutics
Founded2014
LocationUnited States
StageApproved
RevenueEarly Revenue

Trading

TickerIBRX
ExchangeNASDAQ

Therapeutic Areas

OncologyBladder CancerLung CancerGlioblastomaOvarian CancerNon-Hodgkin LymphomaHIVHead and Neck CancerLynch Syndrome

Partners

National Cancer InstituteAIDS Clinical Trials GroupNational Institute of Allergy and Infectious DiseasesVarious clinical trial sites globally
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