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zolbetuximab + Pembrolizumab + Capecitabine + Oxaliplatin + Folinic acid (leucovorin or local equivalent) + 5-fluorouracil (5-FU) + Placebo

Phase 3Recruiting
2 views this week 0 watching⚡ Active🧬Featured in Oncology Pipeline Watch
Interest: 47/100
47
Hype Score

Development Stage

✓
Pre-clinical
✓
Phase 1
✓
Phase 2
4
Phase 3
5
Approved
Indication / Disease

Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer

Conditions

Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

Trial Timeline

May 22, 2025 → Sep 30, 2028

NCT ID
NCT06901531

About zolbetuximab + Pembrolizumab + Capecitabine + Oxaliplatin + Folinic acid (leucovorin or local equivalent) + 5-fluorouracil (5-FU) + Placebo

zolbetuximab + Pembrolizumab + Capecitabine + Oxaliplatin + Folinic acid (leucovorin or local equivalent) + 5-fluorouracil (5-FU) + Placebo is a phase 3 stage product being developed by Astellas Pharma for Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer. The current trial status is recruiting. This product is registered under clinical trial identifier NCT06901531. Target conditions include Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer.

What happened to similar drugs?

5 of 20 similar drugs in Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer were approved

Approved (5) Terminated (1) Active (14)
✅letrozoleJiangsu Hengrui MedicineApproved
✅FulvestrantAstraZenecaApproved
✅PazopanibNovartisApproved
✅LetrozoleNovartisApproved
✅Trastuzumab emtansineRocheApproved
🔄Trastuzumab + Pertuzumab + Docetaxel + Paclitaxel + Nab-paclitaxel + Vinorelbine + Eribulin + Capecitabine + GemcitabineChugai PharmaceuticalPhase 3
🔄Trastuzumab Deruxtecan + Cisplatin + Carboplatin + Pembrolizumab + PemetrexedDaiichi SankyoPhase 3

Hype Score Breakdown

Clinical
17
Activity
15
Company
15
Novelty
0
Community
0

Clinical Trials (1)

NCT IDPhaseStatus
NCT06901531Phase 3Recruiting

Competing Products

20 competing products in Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer

See all competitors
ProductCompanyStageHype Score
Necitumumab + Gemcitabine + CarboplatinEli LillyPhase 2
27
Pemetrexed + Erlotinib + Pemetrexed + ErlotinibEli LillyPhase 2
35
NBTXR3NanobiotixPhase 1/2
33
Tadalafil + GemcitabineEli LillyPhase 1
29
SPYK04Chugai PharmaceuticalPhase 1
33
LUNA18 + CetuximabChugai PharmaceuticalPhase 1
21
Trastuzumab + Pertuzumab + Docetaxel + Paclitaxel + Nab-paclitaxel + Vinorelbine + Eribulin + Capecitabine + GemcitabineChugai PharmaceuticalPhase 3
40
Trastuzumab Deruxtecan + Cisplatin + Carboplatin + Pembrolizumab + PemetrexedDaiichi SankyoPhase 3
44
T-DXd + Durvalumab + Cisplatin + Carboplatin + Pemetrexed + Volrustomig + RilvegostomigDaiichi SankyoPhase 1
36
ASP2998 + Pembrolizumab + Enfortumab Vedotin + CarboplatinAstellas PharmaPhase 1/2
39
zolbetuximabAstellas PharmaPre-clinical
30
enfortumab vedotin + pembrolizumabAstellas PharmaPhase 2
39
zolbetuximab + placebo + oxaliplatin + folinic acid + fluorouracilAstellas PharmaPhase 3
44
enfortumab vedotin (EV)Astellas PharmaPre-clinical
26
zolbetuximabAstellas PharmaPre-clinical
33
zolbetuximab + oxaliplatin + capecitabine + placeboAstellas PharmaPhase 3
44
ASP3082Astellas PharmaPhase 2
42
ASP1948Astellas PharmaPhase 1
29
Camrelizumab + SOX (oxaliplatin + Teggio) /XELOX (oxaliplatin + capecitabine )Sun PharmaceuticalPhase 2
31
Camrelizumab and Apatinib Plus GPSun PharmaceuticalPhase 1/2
28