V180 + Alhydrogel™ + Placebo

Phase 1Completed

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Interest: 29/100

Hype Score

Development Stage

✓

Pre-clinical

Phase 1

Phase 2

Phase 3

Approved

Indication / Disease

Dengue

Conditions

Dengue

Trial Timeline

Apr 1, 2015 → Oct 1, 2015

NCT ID

NCT02450838

About V180 + Alhydrogel™ + Placebo

V180 + Alhydrogel™ + Placebo is a phase 1 stage product being developed by Merck for Dengue. The current trial status is completed. This product is registered under clinical trial identifier NCT02450838. Target conditions include Dengue.

What happened to similar drugs?

0 of 9 similar drugs in Dengue were approved

Approved (0) Terminated (1) Active (8)

🔄Live, attenuated, recombinant dengue serotypes 1, 2, 3, & 4 virus + Live, attenuated, recombinant dengue serotypes 1, 2, 3, & 4 virus + Live, attenuated, recombinant dengue serotypes 1, 2, 3, & 4 virus + Live, attenuated, recombinant dengue serotypes 1, 2, 3, & 4 virus + Placebo: NaCl 0.9%SanofiPhase 3

❌CYD Dengue Vaccine + Tdap: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine adsorbed + Tdap: Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine adsorbedSanofiPhase 3

🔄Live, attenuated, recombinant dengue serotypes 1, 2, 3, and 4 virus + Placebo: NaCl 0.9%SanofiPhase 3

🔄Live, attenuated, dengue serotype 1, 2, 3, 4 virus + Placebo: (NaCl) 0.9% solutionSanofiPhase 3

🔄CYD Dengue Vaccine + CYD Dengue Vaccine + Human Papillomavirus Quadrivalent [Types 6, 11, 16, and 18] Vaccine, Recombinant.SanofiPhase 3

🔄Live, attenuated, dengue serotype 1, 2, 3, 4 virus + Placebo: Sodium chloride (NaCl) 0.9%SanofiPhase 3

🔄Live, attenuated dengue serotype 1, 2, 3, and 4 virus + Yellow fever vaccine + Measles, mumps, and rubella (MMR) vaccine + Pneumococcal Conjugated Vaccine + Hepatitis A Pediatric Vaccine + Diphtheria, tetanus, pertussis, polio, and Haemophilus influenzae vaccine + Live, attenuated dengue serotype 1, 2, 3, and 4 virus + Yellow Fever Vaccine + Placebo (NaCl) + Measles, mumps, and rubella vaccine + Pneumococcal Conjugated Vaccine + Diphtheria, tetanus, pertussis, polio, and Haemophilus influenzae vaccine + Hepatitis A Pediatric VaccineSanofiPhase 3

Hype Score Breakdown

Clinical

Activity

Company

Novelty

Community

Clinical Trials (1)

NCT ID	Phase	Status	Start	Completion	Indication
NCT02450838	Phase 1	Completed	Apr 1, 2015	Oct 1, 2015	Dengue

Competing Products

20 competing products in Dengue

See all competitors

Product	Company	Stage	Hype Score
Low-dose V180 with low-dose ISCOMATRIX™ adjuvant + Low-dose V180 with medium-dose ISCOMATRIX™ adjuvant + Medium-dose V180 (non-adjuvanted) + Medium-dose V180 with low-dose ISCOMATRIX™ adjuvant + Medium-dose V180 with medium-dose ISCOMATRIX™ adjuvant + Medium-dose V180 with Alhydrogel™ adjuvant + High-dose V180 (non-adjuvanted) + High-dose V180 with low-dose ISCOMATRIX™ adjuvant + High-dose V180 with medium-dose ISCOMATRIX™ adjuvant + Low-dose V180 with high-dose ISCOMATRIX™ adjuvant + Medium-dose V180 with high-dose ISCOMATRIX™ adjuvant + High-dose V180 with high-dose ISCOMATRIX™ adjuvant + Placebo	Merck	Phase 1	29
V181 + Butantan - DV	Merck	Phase 2	35
V181 High-Potency Level + V181 Mid-Potency Level + V181 Low-Potency Level + Placebo	Merck	Phase 2	35
EYU688 + Placebo	Novartis	Phase 2	42
balapiravir [RO4588161] + placebo	Roche	Phase 1	29
Dengue Tetravalent Vaccine, Live	Sanofi	Pre-clinical	33
CYD Dengue Vaccine (5-dose formulation) + Placebo, NaCl 0.9%	Sanofi	Phase 2	35
Chimeric dengue serotype (1, 2, 3, 4) + Chimeric dengue serotype (1, 2, 3, 4) + Chimeric dengue serotype (1, 2, 3, 4)	Sanofi	Phase 2	35
Live, attenuated, recombinant dengue serotypes 1, 2, 3, & 4 virus + Live, attenuated, recombinant dengue serotypes 1, 2, 3, & 4 virus + Live, attenuated, recombinant dengue serotypes 1, 2, 3, & 4 virus + Live, attenuated, recombinant dengue serotypes 1, 2, 3, & 4 virus + Placebo: NaCl 0.9%	Sanofi	Phase 3	40
Live, attenuated, recombinant dengue serotype 1 , 2, 3 , and 4 virus + NaCl 0.9% + Tetanus toxoid, reduced diphtheria toxoid, acellular pertussis vaccine adsorbed + Meningococcal A+C vaccine	Sanofi	Phase 2	35
Live, attenuated, recombinant dengue serotypes 1, 2, 3, and 4 virus + Live, attenuated, recombinant dengue serotypes 1, 2, 3, and 4 virus + Live, attenuated, recombinant dengue serotypes 1, 2, 3, and 4 virus + Yellow Fever	Sanofi	Phase 2	35
Tetravalent CYD Dengue Vaccine , 5555 formulation + Tetravalent CYD Dengue Vaccine , 5553 formulation + Tetravalent CYD Dengue Vaccine, 4444 formulation	Sanofi	Phase 2	35
CYD Dengue Vaccine + Tdap: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine adsorbed + Tdap: Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine adsorbed	Sanofi	Phase 3	32
Live, attenuated, recombinant dengue serotypes 1, 2, 3, and 4 virus + Placebo: NaCl 0.9%	Sanofi	Phase 3	40
Live, attenuated, dengue serotype 1, 2, 3, 4 virus + Placebo: (NaCl) 0.9% solution	Sanofi	Phase 3	40
CYD Dengue Vaccine + CYD Dengue Vaccine + Human Papillomavirus Quadrivalent [Types 6, 11, 16, and 18] Vaccine, Recombinant.	Sanofi	Phase 3	40
CYD dengue vaccine serotypes (1, 2, 3, 4). + Meningococcal Polysaccharide A+C; NaCl; Typhoid Vi polysaccharide	Sanofi	Phase 2	35
CYD Dengue Vaccine + Placebo (Sodium chloride 0.9%)	Sanofi	Phase 2	35
CYD Dengue Vaccine + Inactivated rabies virus vaccine + Placebo	Sanofi	Phase 2	35
Live, attenuated, dengue serotype 1, 2, 3, 4 virus + Placebo: Sodium chloride (NaCl) 0.9%	Sanofi	Phase 3	40