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MK-8510

Phase 1Withdrawn
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33
Hype Score

Development Stage

✓
Pre-clinical
2
Phase 1
3
Phase 2
4
Phase 3
5
Approved
Indication / Disease

HIV-1

Conditions

HIV-1, Human Immunodeficiency Virus 1, Immunodeficiency Virus Type 1, Human, Human Immunodeficiency Virus Type 1

Trial Timeline

Apr 17, 2023 → Feb 14, 2024

NCT ID
NCT05700734

About MK-8510

MK-8510 is a phase 1 stage product being developed by Merck for HIV-1. The current trial status is withdrawn. This product is registered under clinical trial identifier NCT05700734. Target conditions include HIV-1, Human Immunodeficiency Virus 1, Immunodeficiency Virus Type 1, Human.

Hype Score Breakdown

Clinical
10
Activity
5
Company
10
Novelty
3
Community
2

Clinical Trials (1)

NCT IDPhaseStatus
NCT05700734Phase 1Withdrawn

Competing Products

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SHR2150；Placebo + SHR2150；Placebo + SHR2150；Placebo + SHR2150；Placebo + SHR2150；PlaceboJiangsu Hengrui MedicinePhase 1
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Darunavir + Etravirine + Emtricitabine/tenofovir disoproxil fumarate + Raltegravir + Second line ART regimens - based on a boosted protease inhibitor (bPI) plus two nucleoside analogues (NRTIs) + Study provided drugs according to patient resistance profile (DRV, ETR, RTV, FTC/TDF) + any in country available drug as applicable & availableAbbVieApproved
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lopinavir/ritonavir + lamivudineAbbViePre-clinical
23
CVC 150 mg + CVC 300 mgAbbViePhase 2
52
Doravirine, Tenofovir, Lamivudine - Blinded + Doravirine, Tenofovir, Lamivudine - Open-Label + ATRIPLA^TM + Placebo to ATRIPLA™ + Placebo to Doravirine, Tenofovir, LamivudineMerckPhase 2
52
DOR/ISL + BIC/FTC/TAF + Placebo to BIC/FTC/TAF + Placebo to DOR/ISLMerckPhase 3
77
VorinostatMerckPhase 1/2
41
IslatravirMerckPhase 1
33
Doravirine, Tenofovir, Lamivudine + Baseline regimen of ritonavir- or cobicistat-boosted protease inhibitor + Baseline regimen of cobicistat-boosted elvitegravir + Baseline regimen of a non-nucleoside reverse transcriptase inhibitor + Baseline regimen of two nucleoside reverse transcriptase inhibitorsMerckPhase 3
77
raltegravir and etravirineMerckPhase 2
52
Treatment A: Doravirine 100 mg film coated tablet + Treatment B: Doravirine 150 mg tablet (40% drug loaded granule) + Treatment C: Doravirine 150 mg tablet (30% drug loaded granule) + Treatment D: Doravirine 150 mg tablet (50% drug loaded granule) + Treatment E: Doravirine 100 mg tablet (30% drug loaded granule)MerckPhase 1
33
ISL + ULO + BIC/FTC/TAFMerckPhase 2
52
UlonivirineMerckPhase 1
33
Islatravir + Placebo to Islatravir + Doravirine + Placebo to Doravirine + Lamivudine + Placebo to Lamivudine + Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate + Placebo to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate + Doravirine/IslatravirMerckPhase 2
52
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33
DoravirineMerckPhase 1
33
18F-RaltegravirMerckPhase 1
33
Pegylated Interferon alpha 2bMerckPhase 2
52
MK-8583MerckPhase 1
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