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Doravirine, Tenofovir, Lamivudine - Blinded + Doravirine, Tenofovir, Lamivudine - Open-Label + ATRIPLA^TM + Placebo to ATRIPLA™ + Placebo to Doravirine, Tenofovir, Lamivudine

Phase 2Completed
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52
Hype Score

Development Stage

✓
Pre-clinical
✓
Phase 1
3
Phase 2
4
Phase 3
5
Approved
Indication / Disease

HIV-1

Conditions

HIV-1, Central Nervous System

Trial Timeline

Mar 4, 2016 → Feb 7, 2024

NCT ID
NCT02652260

About Doravirine, Tenofovir, Lamivudine - Blinded + Doravirine, Tenofovir, Lamivudine - Open-Label + ATRIPLA^TM + Placebo to ATRIPLA™ + Placebo to Doravirine, Tenofovir, Lamivudine

Doravirine, Tenofovir, Lamivudine - Blinded + Doravirine, Tenofovir, Lamivudine - Open-Label + ATRIPLA^TM + Placebo to ATRIPLA™ + Placebo to Doravirine, Tenofovir, Lamivudine is a phase 2 stage product being developed by Merck for HIV-1. The current trial status is completed. This product is registered under clinical trial identifier NCT02652260. Target conditions include HIV-1, Central Nervous System.

Hype Score Breakdown

Clinical
17
Activity
12
Company
10
Novelty
5
Community
5

Clinical Trials (1)

NCT IDPhaseStatus
NCT02652260Phase 2Completed

Competing Products

20 competing products in HIV-1

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ProductCompanyStageHype Score
DOR/ISLMerckPhase 2
52
SHR2150；Placebo + SHR2150；Placebo + SHR2150；Placebo + SHR2150；Placebo + SHR2150；PlaceboJiangsu Hengrui MedicinePhase 1
33
Darunavir + Etravirine + Emtricitabine/tenofovir disoproxil fumarate + Raltegravir + Second line ART regimens - based on a boosted protease inhibitor (bPI) plus two nucleoside analogues (NRTIs) + Study provided drugs according to patient resistance profile (DRV, ETR, RTV, FTC/TDF) + any in country available drug as applicable & availableAbbVieApproved
85
lopinavir/ritonavir + lamivudineAbbViePre-clinical
23
CVC 150 mg + CVC 300 mgAbbViePhase 2
52
DOR/ISL + BIC/FTC/TAF + Placebo to BIC/FTC/TAF + Placebo to DOR/ISLMerckPhase 3
77
VorinostatMerckPhase 1/2
41
IslatravirMerckPhase 1
33
Doravirine, Tenofovir, Lamivudine + Baseline regimen of ritonavir- or cobicistat-boosted protease inhibitor + Baseline regimen of cobicistat-boosted elvitegravir + Baseline regimen of a non-nucleoside reverse transcriptase inhibitor + Baseline regimen of two nucleoside reverse transcriptase inhibitorsMerckPhase 3
77
raltegravir and etravirineMerckPhase 2
52
Treatment A: Doravirine 100 mg film coated tablet + Treatment B: Doravirine 150 mg tablet (40% drug loaded granule) + Treatment C: Doravirine 150 mg tablet (30% drug loaded granule) + Treatment D: Doravirine 150 mg tablet (50% drug loaded granule) + Treatment E: Doravirine 100 mg tablet (30% drug loaded granule)MerckPhase 1
33
ISL + ULO + BIC/FTC/TAFMerckPhase 2
52
UlonivirineMerckPhase 1
33
Islatravir + Placebo to Islatravir + Doravirine + Placebo to Doravirine + Lamivudine + Placebo to Lamivudine + Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate + Placebo to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate + Doravirine/IslatravirMerckPhase 2
52
MK0518 (Raltegravir) + famotidine + omeprazoleMerckPhase 1
33
DoravirineMerckPhase 1
33
MK-8510MerckPhase 1
33
18F-RaltegravirMerckPhase 1
33
Pegylated Interferon alpha 2bMerckPhase 2
52
MK-8583MerckPhase 1
33

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