evolocumab

ApprovedCompleted
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84
Hype Score

Development Stage

โœ“
Pre-clinical
โœ“
Phase 1
โœ“
Phase 2
โœ“
Phase 3
5
Approved
Indication / Disease

Homozygous Familial Hypercholesterolemia HoFH

Conditions

Homozygous Familial Hypercholesterolemia HoFH

Trial Timeline

Aug 4, 2018 โ†’ Nov 27, 2019

About evolocumab

evolocumab is a approved stage product being developed by Amgen for Homozygous Familial Hypercholesterolemia HoFH. The current trial status is completed. This product is registered under clinical trial identifier NCT03403374. Target conditions include Homozygous Familial Hypercholesterolemia HoFH.

Hype Score Breakdown

Clinical
30
Activity
20
Company
9
Novelty
10
Community
12

Clinical Trials (17)

NCT IDPhaseStatus
NCT06140095Phase 1UNKNOWN
NCT04539223ApprovedUNKNOWN
NCT03944577Phase 2Completed
NCT03331666ApprovedTerminated
NCT03403374ApprovedCompleted
NCT03096288ApprovedCompleted
NCT03080935Phase 3Terminated
NCT02957604Pre-clinicalTerminated
NCT02624869Phase 3Completed
NCT02867813Phase 3Completed
NCT02585895Phase 3Completed
NCT02304484Phase 3Completed
NCT02275156Phase 1Completed
NCT01652703Phase 2Completed
NCT01624142Phase 2/3Completed
NCT01439880Phase 2Completed
NCT01380730Phase 2Completed

Competing Products

20 competing products in Homozygous Familial Hypercholesterolemia HoFH

See all competitors
ProductCompanyStageHype Score
Rosuvastatin 20mg + PlaceboAstraZenecaPhase 3
77
Rosuvastatin 20mgAstraZenecaPhase 3
77
Inclisiran + PlaceboNovartisPhase 3
77
Inclisiran Sodium for injection + Placebo + PlacebosNovartisPhase 3
77
InclisiranNovartisPhase 3
77
INC280 + BuparlisibNovartisPhase 1/2
41
Inclisiran + PlaceboNovartisPhase 3
77
Evolocumab + PlaceboAmgenPhase 2/3
64
MBX-8025 50 mg (Dose Escalation Period 1) + MBX-8025 50 mg or 100 mg (Dose Escalation Period 2) + MBX-8025 50 mg, 100 mg or 200 mg (Dose Escalation Period 3)Gilead SciencesPhase 2
51
IBI306 + IBI306Innovent BiologicsPhase 2/3
64
BMS-986504 + [14C]-BMS-986504Bristol Myers SquibbPhase 1
32
Lumacaftor Plus Ivacaftor Combination + Ivacaftor + PlaceboVertex PharmaceuticalsPhase 3
76
Placebo + Lumacaftor Plus Ivacaftor Combination + IvacaftorVertex PharmaceuticalsPhase 3
76
Lumacaftor Plus Ivacaftor Combination + IvacaftorVertex PharmaceuticalsPhase 3
76
Alirocumab + PlaceboSanofiPhase 3
76
AK102 + Statins + EzetimibeAkesoPhase 2
51
EvinacumabRegeneron PharmaceuticalsPhase 3
76
evinacumabRegeneron PharmaceuticalsPhase 3
76
REGN1500 250 mg SC/15 mg/kg IV/450 mg SCRegeneron PharmaceuticalsPhase 2
51
EvinacumabRegeneron PharmaceuticalsPre-clinical
22