AXS-05 (dextromethorphan-bupropion)

Phase 3Terminated
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Interest: 29/100
29
Hype Score

Development Stage

Pre-clinical
Phase 1
Phase 2
4
Phase 3
5
Approved
Indication / Disease

Agitation in Patients With Dementia of the Alzheimer's Type

Conditions

Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease, Agitation, Psychomotor

Trial Timeline

Nov 21, 2024 → Apr 25, 2025

About AXS-05 (dextromethorphan-bupropion)

AXS-05 (dextromethorphan-bupropion) is a phase 3 stage product being developed by Axsome Therapeutics for Agitation in Patients With Dementia of the Alzheimer's Type. The current trial status is terminated. This product is registered under clinical trial identifier NCT06736509. Target conditions include Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease, Agitation, Psychomotor.

What happened to similar drugs?

2 of 13 similar drugs in Agitation in Patients With Dementia of the Alzheimer's Type were approved

Approved (2) Terminated (1) Active (10)
Dexmedetomidine + Lorazepam 2 MG/MLBioXcel TherapeuticsApproved
🔄Brexpiprazole, OPC-34712LundbeckPhase 3
🔄BrexpiprazoleLundbeckPhase 3
🔄AXS-05 (dextromethorphan-bupropion) + PlaceboAxsome TherapeuticsPhase 3
🔄AXS-05 + PlaceboAxsome TherapeuticsPhase 3

Hype Score Breakdown

Clinical
17
Activity
0
Company
12
Novelty
0
Community
0

Clinical Trials (2)

NCT IDPhaseStatus
NCT06736509Phase 3Terminated
NCT04634669Phase 2Terminated

Competing Products

20 competing products in Agitation in Patients With Dementia of the Alzheimer's Type

See all competitors
ProductCompanyStageHype Score
ONO-2020 + PlaceboOno PharmaceuticalPhase 2
42
Quetiapine + Haloperidol + Lorazepam + CogentinAstraZenecaApproved
43
Brexpiprazole, OPC-34712LundbeckPhase 3
37
Brexpiprazole, OPC-34712 + Placebo Oral TabletLundbeckPhase 3
37
BrexpiprazoleLundbeckPhase 3
37
AXS-05 (dextromethorphan-bupropion) + PlaceboAxsome TherapeuticsPhase 3
37
AXS-05 + Bupropion + PlaceboAxsome TherapeuticsPhase 2/3
35
AXS-05 + PlaceboAxsome TherapeuticsPhase 3
37
AXS-05 + PlaceboAxsome TherapeuticsPhase 3
37
Pimavanserin 34 mg + Pimavanserin 20 mgAcadia PharmaceuticalsPhase 2
24
PimavanserinAcadia PharmaceuticalsPhase 2
32
Sublingual film containing Dexmedetomidine (BXCL501) + Placebo FilmBioXcel TherapeuticsPhase 3
30
BXCL501 + Matching PlaceboBioXcel TherapeuticsPhase 3
22
Sublingual film containing BXCL501 (Dexmedetomidine) + Placebo filmBioXcel TherapeuticsPhase 1
19
BXCL501 + Matching PlaceboBioXcel TherapeuticsPhase 3
30
BXCL501 + Matching PlaceboBioXcel TherapeuticsPhase 3
30
Sublingual film containing dexmedetomidine (BXCL501) + Placebo FilmBioXcel TherapeuticsPhase 3
30
BXCL501 + BXCL501 + Placebo filmBioXcel TherapeuticsPhase 2
17
BXCL501 + Placebo filmBioXcel TherapeuticsPhase 2
17
Sublingual film containing Dexmedetomidine + Sublingual Placebo FilmBioXcel TherapeuticsPhase 1/2
22