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Tebipenem HBr (tebipenem pivoxil hydrobromide)

Complicated Urinary Tract Infection (cUTI), including pyelonephritis

Phase 3Active - Phase 3 met primary endpoint (May 2025)

Key Facts

Indication
Complicated Urinary Tract Infection (cUTI), including pyelonephritis
Phase
Phase 3
Status
Active - Phase 3 met primary endpoint (May 2025)
Company

About Spero Therapeutics

Spero Therapeutics is a Boston-based biotech focused on rare diseases and antibiotic-resistant infections, leveraging a capital-efficient, partnership-driven model. Its defining achievement is the positive Phase 3 readout for tebipenem HBr, an oral carbapenem for complicated urinary tract infections, which could become the first oral drug in its class and offers a paradigm shift from IV to oral treatment. The company's strategy involves in-licensing and developing assets with clear differentiation, targeting areas with scarce therapeutic options. With a lean team and a history of strategic collaborations, Spero is poised to advance its lead candidate toward regulatory submission while exploring its pipeline.

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