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NX-2127

Relapsed/Refractory B-cell Malignancies

Phase 1aActive

Key Facts

Indication
Relapsed/Refractory B-cell Malignancies
Phase
Phase 1a
Status
Active
Company

About Nurix Therapeutics

Nurix Therapeutics is a leader in the targeted protein degradation (TPD) space, with a mission to develop breakthrough therapies for cancer and autoimmune diseases by harnessing the body's natural protein disposal systems. The company's core achievement is the development of its integrated DELigase™ discovery platform, which combines DNA-encoded libraries (DEL), artificial intelligence (AI), and deep E3 ligase expertise to rapidly generate novel degrader candidates. Its strategy involves advancing a multi-modal pipeline of oral degraders and antibody-conjugated degraders (DACs), with its lead asset, bexobrutideg (NX-5948), in Phase 2 trials for hematologic cancers. Nurix aims to establish degrader-based medicines as a cornerstone of future patient care through both internal development and strategic partnerships.

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Other Relapsed/Refractory B-cell Malignancies Drugs

DrugCompanyPhase
UB-VV111Umoja BiopharmaPhase 1
Bexobrutideg (NX-5948)Nurix TherapeuticsPhase 1a/1b
FT819Fate TherapeuticsPhase 1