Fate Therapeutics

Fate Therapeutics

FATEPhase 2
San Diego, United Statesfatetherapeutics.com

Fate Therapeutics is dedicated to transforming patient lives with autoimmune diseases and cancer through its proprietary iPSC platform, which generates 'off-the-shelf' cell therapies. The company's mission is to make cell therapy delivery routine and accessible by developing multiplexed-engineered cell product candidates that incorporate novel synthetic controls of cell function. Its pipeline includes several clinical-stage candidates, such as FT819, FT825, FT836, FT839, and FT522, targeting both oncology and autoimmune indications. Fate operates as a public company, leveraging strategic collaborations to advance its science and clinical development.

Market Cap
$127.9M
Focus
BiologicsSmall MoleculesCell & Gene Therapy

FATE · Stock Price

USD 1.1036.90 (-97.11%)

Historical price data

AI Company Overview

Fate Therapeutics is dedicated to transforming patient lives with autoimmune diseases and cancer through its proprietary iPSC platform, which generates 'off-the-shelf' cell therapies. The company's mission is to make cell therapy delivery routine and accessible by developing multiplexed-engineered cell product candidates that incorporate novel synthetic controls of cell function. Its pipeline includes several clinical-stage candidates, such as FT819, FT825, FT836, FT839, and FT522, targeting both oncology and autoimmune indications. Fate operates as a public company, leveraging strategic collaborations to advance its science and clinical development.

Technology Platform

Proprietary induced pluripotent stem cell (iPSC) platform used to create clonal master cell lines for the scalable, off-the-shelf manufacturing of multiplexed-engineered cell therapies, including CAR T-cells, NK cells, and regulatory T-cells (Tregs).

Pipeline Snapshot

21

21 drugs in pipeline

DrugIndicationStageWatch
ProHema-CB + Untreated CBHematologic MalignanciesPhase 2
ProTmune + Control ArmHematologic MalignanciesPhase 1/2
FT516 + Rituximab + Obinutuzumab + Cyclophosphamide + Fludarabine + IL-2 + Benda...Acute Myelogenous LeukemiaPhase 1
FT596 + Cyclophosphamide + Fludarabine + Rituximab + Obinutuzumab + BendamustineLymphoma, B-CellPhase 1
FT596 + Cyclophosphamide + Doxorubicin + Vincristine + Prednisone + Rituximab + ...Diffuse Large B Cell LymphomaPhase 1

Funding History

4

Total raised: $272M

PIPE$175MUndisclosedDec 15, 2020
IPO$60MUndisclosedNov 7, 2013
Series B$25MOppenheimer & Co.Jun 15, 2010
Series A$12MVersant VenturesJun 15, 2007

Opportunities

The primary growth opportunity lies in successfully validating its iPSC platform, which could enable a pipeline of 'off-the-shelf' cell therapies for large oncology and autoimmune markets.
Demonstrating clinical efficacy and a scalable manufacturing advantage could lead to major pharmaceutical partnerships, accelerated development, and ultimately, market leadership in the allogeneic cell therapy space.

Risk Factors

Key risks include clinical trial failures, regulatory hurdles for novel iPSC-derived therapies, manufacturing scalability challenges, intense competition from both autologous and other allogeneic approaches, and dependence on raising capital as a pre-revenue company.

Competitive Landscape

Fate competes with other allogeneic cell therapy companies like Allogene Therapeutics and CRISPR Therapeutics, as well as autologous leaders like Novartis and Gilead. Its key differentiation is the use of a clonal iPSC starting material, which aims to provide superior scalability, consistency, and capacity for complex genetic engineering compared to donor-derived approaches.

Company Info

TypeTherapeutics
LocationSan Diego, United States
StagePhase 2
RevenuePre-revenue

Trading

TickerFATE
ExchangeNASDAQ

Therapeutic Areas

OncologyAutoimmune Diseases

Partners

Duke University Health SystemM. D. Anderson Cancer CenterThomas Jefferson University, Sidney Kimmel Cancer CenterUniversity of Minnesota Masonic Cancer CenterThe University of Texas MD Anderson Cancer CenterSarah Cannon Research Institute (SCRI) – Oncology PartnersOU Health Stephenson Cancer CenterOhio State University – Comprehensive Cancer Center
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