GH001

Treatment-Resistant Depression (TRD)

Phase 2b/3Phase 2b completed; Phase 3 initiation planned for 2026NCT05674981

Key Facts

Indication
Treatment-Resistant Depression (TRD)
Phase
Phase 2b/3
Status
Phase 2b completed; Phase 3 initiation planned for 2026
Company

About GH Research

GH Research is an Irish biotech company founded in 2018 with a mission to revolutionize the treatment of severe psychiatric disorders through its innovative mebufotenin-based platform. Its core achievement is the development of the Individualized Dosing Regimen (IDR), which has demonstrated high remission rates in early trials for treatment-resistant depression. The company's strategy is to advance its lead inhaled formulation, GH001, through late-stage clinical development for multiple indications, leveraging its strong intellectual property portfolio and aiming to address a massive unmet need with a potentially paradigm-shifting therapy.

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About GH Research

GH Research is an Irish biotech company founded in 2018 with a mission to revolutionize the treatment of severe psychiatric disorders through its innovative mebufotenin-based platform. Its core achievement is the development of the Individualized Dosing Regimen (IDR), which has demonstrated high remission rates in early trials for treatment-resistant depression. The company's strategy is to advance its lead inhaled formulation, GH001, through late-stage clinical development for multiple indications, leveraging its strong intellectual property portfolio and aiming to address a massive unmet need with a potentially paradigm-shifting therapy.

View full company profile

About GH Research

GH Research is an Irish biotech company founded in 2018 with a mission to revolutionize the treatment of severe psychiatric disorders through its innovative mebufotenin-based platform. Its core achievement is the development of the Individualized Dosing Regimen (IDR), which has demonstrated high remission rates in early trials for treatment-resistant depression. The company's strategy is to advance its lead inhaled formulation, GH001, through late-stage clinical development for multiple indications, leveraging its strong intellectual property portfolio and aiming to address a massive unmet need with a potentially paradigm-shifting therapy.

View full company profile

Therapeutic Areas

Other Treatment-Resistant Depression (TRD) Drugs

DrugCompanyPhase
CYC-126Cyclerion TherapeuticsPhase 1
DOTMotif NeurotechPre-clinical
FMP374FundaMental PharmaPreclinical
R-107Tasman TherapeuticsPhase 3
COMP360 Psilocybin TherapyCompass PathwaysPhase 3
Ketamir-2 (Ketamir)MIRA PharmaceuticalsPhase 1