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Motif Neurotech

Motif Neurotech

San Francisco, United States· Est.
motifneuro.tech
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Private Company

Total funding raised: $12.5M

Overview

Motif Neurotech is a private, pre-revenue medical device company pioneering a novel therapeutic brain-computer interface (BCI) for mental health. Its lead program targets treatment-resistant depression with a pea-sized, wirelessly powered implant (DOT) that stimulates the brain's Central Executive Network via a wearable hat, aiming to rebalance neural activity. Founded by CEO Jacob Robinson, PhD, the company leverages patent-pending magnetoelectric power transfer technology from Rice University and is building a patient registry while progressing toward clinical trials.

PsychiatryNeuroscience

Technology Platform

DOT therapeutic brain-computer interface (BCI): a miniaturized, wirelessly powered (magnetoelectric) implant that delivers targeted stimulation to specific brain networks via a wearable device, without contacting the brain.

Funding History

1
Total raised:$12.5M
Seed$12.5M

Opportunities

Addresses a large unmet need in the multi-billion dollar treatment-resistant depression market, where approximately one-third of patients do not respond to drugs.
The minimally invasive, at-home platform has potential for expansion into other neuropsychiatric disorders like anxiety or OCD, significantly increasing its addressable market.

Risk Factors

Faces significant technical and clinical risk in proving the efficacy and safety of its novel brain stimulation approach in human trials.
Regulatory pathway for an implantable psychiatric device is long and uncertain, and commercialization will require overcoming physician adoption and insurance reimbursement hurdles.

Competitive Landscape

Operates in the competitive neuromodulation space, facing established players with TMS devices and other BCI companies (e.g., Neuralink, Synchron) developing interfaces for various indications. Differentiation hinges on its minimally invasive, wirelessly powered approach specifically tailored for psychiatric applications.

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