Temisis

Temisis

Paris, France· Est.
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Private Company

Funding information not available

Overview

Temisis Therapeutics is a Paris-based, private biotech advancing novel small molecules for inflammatory diseases, with a primary focus on psoriasis. Its lead asset, TEM-1657, has shown in preclinical models to achieve rapid symptom remission and complete healing without the side effects, such as skin thinning, associated with current corticosteroids or oral therapies like apremilast. The company is positioned to address a significant unmet need in a large global market, though it remains at a preclinical stage with no disclosed clinical data, partnerships, or financing details.

Inflammatory DiseasesDermatologyAutoimmune Diseases

Technology Platform

Proprietary small molecules targeting the Th17/IL-23 inflammatory axis, designed to separate efficacy from side effects like skin atrophy.

Opportunities

Addressing a large global psoriasis market with significant unmet need for safer, effective therapies.
A successful topical agent without steroid-like side effects could become a first-line standard, while an oral drug with a clean profile could compete in the systemic market.
The Th17/IL-23 target also offers potential for expansion into other chronic inflammatory diseases.

Risk Factors

High risk of failure in translating compelling preclinical data into human efficacy and safety.
The company is pre-revenue and dependent on securing future funding to advance.
It operates in the highly competitive psoriasis market against established biologics and oral therapies.

Competitive Landscape

Competes in the crowded psoriasis market against topical corticosteroids/calcipotriene, oral small molecules (apremilast, deucravacitinib), and numerous injectable biologics (anti-TNF, IL-17, IL-23 inhibitors). Key differentiation claims are a superior safety profile versus steroids (no skin thinning) and oral PDE4 inhibitors (fewer side effects).