RotaChrom Technologies

RotaChrom Technologies is a private company specializing in a novel purification technology called Centrifugal Partition Chromatography (CPC), which replaces traditional solid-phase silica columns with a liquid-liquid separation process. This approach offers advantages for purifying complex small molecules, including high selectivity, scalability, gentle handling of sensitive compounds, and elimination of silica-related issues like irreversible adsorption. The company operates a platform-plus-services business model, selling benchtop to industrial-scale CPC systems, digital development tools, and expert-led purification services to the pharma, biotech, botanicals, nutraceuticals, and cosmetics industries.

Centrifugal Partition Chromatography (CPC), a liquid-liquid chromatography technique that uses immiscible liquid phases instead of a solid stationary phase (like silica) for the purification of complex small molecules and natural products.

Competes against dominant solid-phase chromatography vendors (Agilent, Waters, Thermo Fisher) and alternative purification techniques like crystallization and simulated moving bed (SMB) chromatography. Differentiation is based on silica-free operation, inherent scalability, and gentle processing for sensitive compounds.