MeiraGTx

MeiraGTx

MGTX
Is this your company? Claim your profile to update info and connect with investors.
Claim profile

MGTX · Stock Price

USD 9.68+4.26 (+78.60%)
Market Cap: $894.3M

Historical price data

Market Cap: $894.3MPipeline: 7 drugsFounded: 2015HQ: New York, United States

Overview

MeiraGTx is a clinical-stage biotech focused on translating advanced genetic medicine into transformative therapies for diseases with high unmet need. Its strategy is built on a fully integrated platform combining novel vector engineering, precision gene control via its riboswitch technology, and in-house GMP manufacturing. Key achievements include a late-stage pipeline with Breakthrough Therapy designation for its xerostomia program and a major strategic collaboration with Eli Lilly in ophthalmology, positioning the company for significant value inflection.

OphthalmologyNeurodegenerationMetabolic DisordersOncology

Technology Platform

Proprietary platform featuring optimized AAV vector engineering, tissue-specific promoters, and a transformative riboswitch gene regulation system enabling precise, oral small molecule-controlled transgene expression for a wide range of diseases.

Pipeline

7
7 drugs in pipeline
DrugIndicationStageWatch
AAV RPE65Leber Congenital AmaurosisPhase 1/2
AAV - CNGB3AchromatopsiaPhase 1/2
adeno-associated virus vector AAV- CNGA3AchromatopsiaPhase 1/2
AAV2hAQP1Squamous Cell Head and Neck CancerPhase 1
AAV2hAQP1: 1 x 10^11 vg/gland (single gland) + AAV2hAQP1: 3 ...Radiation-Induced Parotid Gland HypofunctionPhase 1

Funding History

2
Total raised:$120M
IPO$75M
Series B$45M

Opportunities

MeiraGTx has near-term value drivers in its late-stage ophthalmology and xerostomia programs, with Breakthrough Therapy designation de-risking the latter.
The long-term, transformative opportunity lies in its riboswitch platform, which could enable single-administration, regulated treatments for massive chronic disease markets like obesity and diabetes.

Risk Factors

Key risks include clinical trial failures in its Phase 3 programs, unproven safety/efficacy of the novel riboswitch platform in humans, regulatory hurdles for gene therapies, and future capital needs potentially leading to shareholder dilution.
Competition in genetic medicine is intense and evolving rapidly.

Competitive Landscape

MeiraGTx competes in ophthalmology with established gene therapy players like Roche/Spark, but its riboswitch platform is a key differentiator with few direct peers. The Eli Lilly partnership validates its ophthalmology approach. In large chronic diseases, its riboswitch technology positions it against major pharma companies but with a fundamentally different, potentially disruptive modality.

Company Timeline

2015Founded

Founded in New York, United States

2017Series B

Series B: $45.0M

2018IPO

IPO — $75.0M