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Loci Orthopaedics

Loci Orthopaedics

Galway, Ireland· Est.
lociorthopaedics.com
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Private Company

Total funding raised: $10.5M

Overview

Loci Orthopaedics is a private, pre-revenue medical device company founded in 2015, developing targeted orthopaedic implants for extremity joints, starting with the thumb. Its lead product, the InDx implant, is designed to address the significant unmet need in thumb base arthritis (trapeziometacarpal joint osteoarthritis), a condition affecting millions globally, particularly women over 55. The company leverages evidence-based design and a seasoned leadership team with extensive medtech experience in R&D, commercialization, and successful exits to advance its technology towards clinical use and regulatory approval.

OrthopaedicsOsteoarthritis

Technology Platform

Evidence-based design platform for developing orthopaedic implants for extremity joints, beginning with the thumb.

Funding History

2
Total raised:$10.5M
Series A$8M
Seed$2.5M

Opportunities

The significant unmet need in thumb base arthritis, affecting millions globally with limited surgical options, presents a clear market entry point.
Demographic trends and a growing focus on the extremities segment within orthopaedics provide a favorable long-term market environment.
A successful product could expand the treatable patient population by offering a superior alternative to current procedures.

Risk Factors

The company faces high technical and clinical risk in transitioning its implant to human use, alongside the substantial regulatory and reimbursement hurdles inherent to new medical devices.
As a pre-revenue start-up, it also carries commercialization risk in competing against established surgical techniques and potential future competitors with greater resources.

Competitive Landscape

Competition primarily consists of established surgical techniques (trapeziectomy, arthrodesis) and possibly other early-stage implant developers. Large orthopaedic companies have extremities divisions but may not have a focused thumb TMC implant. Loci's competition is therefore the entrenched standard of care rather than a directly comparable device, which is both a challenge (changing surgeon behavior) and an opportunity (first-mover advantage).

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