Enterome

Enterome

Paris, France· Est.
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Private Company

Total funding raised: $135.2M

Overview

Enterome is a pioneering French biotech translating microbiome science into innovative cancer immunotherapies. Its proprietary Mimicry platform screens a vast database of gut microbiome proteins to discover OncoMimics™, off-the-shelf peptide therapies designed to overcome immune tolerance. The company has advanced three Phase 2 candidates targeting glioblastoma, lymphomas, adrenal tumors, and colorectal cancer, demonstrating promising early efficacy and safety. With strong leadership and significant capital raised, Enterome is positioned as a key player in the next wave of immuno-oncology.

Oncology

Technology Platform

Proprietary Mimicry platform that uses biocomputational tools to mine a database of 20+ million gut microbiome proteins to identify OncoMimics™ peptides. These peptides mimic tumor antigens and reactivate pre-existing memory T cells to attack cancer.

Funding History

4
Total raised:$135.2M
Series D$56.7M
Series C$46.5M
Series B$17M
Series A$15M

Opportunities

The successful validation of its OncoMimics™ platform could unlock a new class of off-the-shelf cancer immunotherapies for multiple solid tumors with high unmet need.
Positive Phase 2 data creates strong potential for strategic partnerships or licensing deals with large pharmaceutical companies, providing non-dilutive funding and development expertise.
Expansion into additional oncology indications and combination regimens with existing therapies (e.g., checkpoint inhibitors) represent significant future growth avenues.

Risk Factors

The company faces high clinical development risk, as its promising Phase 2 data must be confirmed in larger, more rigorous Phase 3 trials for regulatory approval.
As a pre-revenue company with a single-platform focus, it is vulnerable to clinical setbacks, financing market volatility, and intense competition from established immuno-oncology players with greater resources.

Competitive Landscape

Enterome competes in the crowded cancer immunotherapy space against dominant checkpoint inhibitors, targeted therapies, and cell therapies. Its primary differentiation is its novel microbiome-derived, off-the-shelf peptide approach, which contrasts with personalized cell therapies. Competitors include other biotechs developing cancer vaccines and peptide-based immunotherapies, though few leverage the gut microbiome as a drug discovery source.