Cellectis
CLLSCLLS · Stock Price
Historical price data
Overview
Cellectis is a French-American biotech leader focused on developing universal, allogeneic CAR T-cell therapies using its proprietary TALEN® gene-editing technology. The company's core strategy is to overcome the manufacturing complexity, high cost, and treatment delays associated with autologous CAR-Ts by creating 'off-the-shelf' products from healthy donor cells. Its most advanced candidate, lasme-cel (UCART22), has shown compelling Phase 1 efficacy and safety in relapsed/refractory B-ALL, triggering the initiation of a pivotal Phase 2 trial with a projected peak sales opportunity of ~$700M. Cellectis sustains its innovation through a strong IP estate and strategic partnerships with companies like Allogene and Servier.
Technology Platform
Proprietary TALEN® gene-editing technology and PulseAgile® electroporation system for creating precision-engineered, allogeneic 'off-the-shelf' CAR T-cell therapies.
Pipeline
6| Drug | Indication | Stage | Watch |
|---|---|---|---|
| UCART22 + CLLS52 | B-cell Acute Lymphoblastic Leukemia | Phase 1/2 | |
| UCART20x22 + CLLS52 | B-cell Non-Hodgkin Lymphoma (B-NHL) | Phase 1/2 | |
| UCART123 | Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) | Phase 1 | |
| UCART123v1.2 | Relapsed/Refractory Acute Myeloid Leukemia | Phase 1 | |
| UCART123 | Acute Myeloid Leukaemia | Phase 1 |
Funding History
3Opportunities
Risk Factors
Competitive Landscape
Cellectis competes with other allogeneic CAR-T developers like Allogene, CRISPR Therapeutics, and Precision BioSciences, as well as dominant autologous CAR-T leaders. Its differentiation lies in the proprietary TALEN® gene-editing system, known for high specificity, and an integrated non-viral manufacturing platform.
Company Timeline
Founded in Paris, France
Series A: $10.0M
IPO — $60.0M
PIPE: $228.0M