Cellectis

Cellectis

CLLS
Paris, France· Est.
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CLLS · Stock Price

USD 3.86+2.28 (+144.30%)
Market Cap: $388.3M

Historical price data

Market Cap: $388.3MPipeline: 6 drugsPatents: 20Founded: 1999Employees: 200-500HQ: Paris, France

Overview

Cellectis is a French-American biotech leader focused on developing universal, allogeneic CAR T-cell therapies using its proprietary TALEN® gene-editing technology. The company's core strategy is to overcome the manufacturing complexity, high cost, and treatment delays associated with autologous CAR-Ts by creating 'off-the-shelf' products from healthy donor cells. Its most advanced candidate, lasme-cel (UCART22), has shown compelling Phase 1 efficacy and safety in relapsed/refractory B-ALL, triggering the initiation of a pivotal Phase 2 trial with a projected peak sales opportunity of ~$700M. Cellectis sustains its innovation through a strong IP estate and strategic partnerships with companies like Allogene and Servier.

OncologyGenetic Diseases

Technology Platform

Proprietary TALEN® gene-editing technology and PulseAgile® electroporation system for creating precision-engineered, allogeneic 'off-the-shelf' CAR T-cell therapies.

Pipeline

6
6 drugs in pipeline
DrugIndicationStageWatch
UCART22 + CLLS52B-cell Acute Lymphoblastic LeukemiaPhase 1/2
UCART20x22 + CLLS52B-cell Non-Hodgkin Lymphoma (B-NHL)Phase 1/2
UCART123Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)Phase 1
UCART123v1.2Relapsed/Refractory Acute Myeloid LeukemiaPhase 1
UCART123Acute Myeloid LeukaemiaPhase 1

Funding History

3
Total raised:$298M
PIPE$228M
IPO$60M
Series A$10M

Opportunities

The lead candidate, lasme-cel, addresses a significant unmet need in late-line B-ALL with a potential $700M peak sales opportunity.
Success could validate the allogeneic platform, enabling expansion into larger oncology markets and partnerships in non-oncology gene therapy.

Risk Factors

High clinical risk associated with pivotal Phase 2 trial outcomes.
The company faces intense competition in the allogeneic CAR-T space, has a limited cash runway requiring future financing, and carries technological risk if newer editing platforms gain dominance.

Competitive Landscape

Cellectis competes with other allogeneic CAR-T developers like Allogene, CRISPR Therapeutics, and Precision BioSciences, as well as dominant autologous CAR-T leaders. Its differentiation lies in the proprietary TALEN® gene-editing system, known for high specificity, and an integrated non-viral manufacturing platform.

Company Timeline

1999Founded

Founded in Paris, France

2000Series A

Series A: $10.0M

2015IPO

IPO — $60.0M

2015PIPE

PIPE: $228.0M