Alveron Pharma

Alveron Pharma

Pre-clinical
Utrecht, NetherlandsFounded 2020alveron.com

Alveron Pharma is a private, pre-clinical stage biotech focused on revolutionizing the treatment of life-threatening bleeds caused by anticoagulants. Its lead candidate, OKL-1111, is a synthetic, universal reversal agent designed for rapid administration in emergencies like hemorrhagic stroke, potentially cutting treatment delays from over an hour to minutes. The company is backed by European venture capital and leverages a management team with deep experience in coagulation therapeutics and drug development.

Founded
2020
Focus
OncologyAntibodies

AI Company Overview

Alveron Pharma is a private, pre-clinical stage biotech focused on revolutionizing the treatment of life-threatening bleeds caused by anticoagulants. Its lead candidate, OKL-1111, is a synthetic, universal reversal agent designed for rapid administration in emergencies like hemorrhagic stroke, potentially cutting treatment delays from over an hour to minutes. The company is backed by European venture capital and leverages a management team with deep experience in coagulation therapeutics and drug development.

Technology Platform

A unique coagulation platform based on a synthetic cyclodextrin molecule engineered to universally bind and neutralize a wide range of anticoagulant and antiplatelet drugs, enabling rapid reversal without requiring prior drug identification.

Funding History

3

Total raised: $22M

Seed$3.5MBioGeneration VenturesJun 15, 2022
Series A$15MBioGeneration VenturesMay 15, 2022
Seed$3.5MBioGeneration VenturesSep 15, 2020

Opportunities

The primary opportunity is to establish OKL-1111 as the first universal, rapid-response therapy for life-threatening bleeds in anticoagulated patients, fundamentally changing emergency stroke care.
Long-term expansion includes pre-hospital (ambulance) use paired with mobile scanning tech, and addressing bleeds from antiplatelet agents which lack specific antidotes.

Risk Factors

Key risks include pre-clinical translational risk, the challenge of demonstrating improved outcomes in complex stroke trials, competition from established agent-specific therapies, regulatory hurdles for a novel universal agent, and dependence on a single lead candidate for company value.

Competitive Landscape

Competes against specific reversal agents (e.g., Andexxa, Praxbind) and non-specific options (PCC, Vitamin K). Key differentiation is OKL-1111's universal mechanism against multiple anticoagulant/antiplatelet classes, ready-to-use formulation for speed, and a synthetic cyclodextrin platform with a potentially favorable safety profile.

Company Info

TypeTherapeutics
Founded2020
LocationUtrecht, Netherlands
StagePre-clinical
RevenuePre-revenue

Therapeutic Areas

HematologyNeurologyCardiovascular

Partners

OKKLO BVSanquin (Dutch blood foundation)
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