Tofersen

ApprovedRecruiting

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Interest: 47/100

Hype Score

Development Stage

✓

Pre-clinical

✓

Phase 1

✓

Phase 2

✓

Phase 3

Approved

Indication / Disease

Amyotrophic Lateral Sclerosis

Conditions

Amyotrophic Lateral Sclerosis

Trial Timeline

Dec 11, 2025 → Dec 16, 2027

NCT ID

NCT07223723

About Tofersen

Tofersen is a approved stage product being developed by Biogen for Amyotrophic Lateral Sclerosis. The current trial status is recruiting. This product is registered under clinical trial identifier NCT07223723. Target conditions include Amyotrophic Lateral Sclerosis.

What happened to similar drugs?

1 of 17 similar drugs in Amyotrophic Lateral Sclerosis were approved

Approved (1) Terminated (4) Active (12)

🔄methylcobalamin + saline solutionEisaiPhase 3

🔄Olesoxime + Placebo Comparator + RiluzoleRochePhase 3

✅RiluzoleSanofiApproved

🔄Tofersen + PlaceboBiogenPhase 3

❌DexpramipexoleBiogenPhase 3

🔄ION363 + PlaceboIonis PharmaceuticalsPhase 3

Hype Score Breakdown

Clinical

Activity

Company

Novelty

Community

Clinical Trials (5)

NCT ID	Phase	Status	Start	Completion	Indication
NCT04972487	Pre-clinical	Completed	—	—	Superoxide Dismutase 1-Amyotropic Lateral Sclerosis
NCT07259980	Pre-clinical	Recruiting	Mar 31, 2026	Dec 30, 2033	Amyotrophic Lateral Sclerosis
NCT07294144	Phase 2	Recruiting	Dec 29, 2025	May 1, 2028	ALS (Amyotrophic Lateral Sclerosis)
NCT07223723	Approved	Recruiting	Dec 11, 2025	Dec 16, 2027	Amyotrophic Lateral Sclerosis
NCT03070119	Phase 3	Completed	Mar 8, 2017	Aug 12, 2024	ALS Caused by Superoxide Dismutase 1 (SOD1) Mutation

Competing Products

20 competing products in Amyotrophic Lateral Sclerosis

See all competitors

Product	Company	Stage	Hype Score
AL001 + Placebo	Alector	Phase 2	17
89Zr-DFO-AP-101	Eli Lilly	Phase 1	33
Reldesemtiv + Placebo	Astellas Pharma	Phase 2	35
Perampanel + Placebo Oral Tablet	Eisai	Pre-clinical	18
E0302 (mecobalamin)	Eisai	Phase 2/3	38
E0302 (mecobalamin) + E0302 (mecobalamin) + Placebo	Eisai	Phase 2/3	38
methylcobalamin + saline solution	Eisai	Phase 3	40
ONO-2506PO	Ono Pharmaceutical	Phase 2	35
ONO-2506PO + ONO-2506PO	Ono Pharmaceutical	Phase 2	35
ZYIL1 capsules 25 mg and 50 mg Placebo + ZYIL1 capsules 50 mg and 25 mg Placebo + ZYIL1 capsules 25 mg and ZYIL1 capsules 50 mg + Matching placebo 25 mg and Matching placebo 50 mg	Zydus Lifesciences	Phase 2	35
LY4256984 + Placebo	Eli Lilly	Phase 1	36
TCH346	Novartis	Phase 2	35
VHB937	Novartis	Phase 2	39
TCH346	Novartis	Phase 2	35
TCH346	Novartis	Phase 2	35
BLZ945	Novartis	Phase 2	27
TRO19622	Roche	Phase 2/3	38
Olesoxime + Placebo Comparator + Riluzole	Roche	Phase 3	40
Bosutinib (Phase 1 part) + Bosutinib (Phase 2 part)	Pfizer	Phase 1/2	28
Celecoxib + Creatine + Minocycline	Pfizer	Phase 2	35