Temozolomide

ApprovedCompleted

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Interest: 43/100

Hype Score

Development Stage

✓

Pre-clinical

✓

Phase 1

✓

Phase 2

✓

Phase 3

Approved

Indication / Disease

Glioblastoma

Conditions

Glioblastoma

Trial Timeline

Jun 24, 2008 → Sep 28, 2011

NCT ID

NCT00686725

About Temozolomide

Temozolomide is a approved stage product being developed by Merck for Glioblastoma. The current trial status is completed. This product is registered under clinical trial identifier NCT00686725. Target conditions include Glioblastoma.

What happened to similar drugs?

0 of 17 similar drugs in Glioblastoma were approved

Approved (0) Terminated (1) Active (16)

🔄enzastaurin + lomustineEli LillyPhase 3

🔄DSP-7888 Dosing Emulsion + BevacizumabSumitomo PharmaPhase 3

🔄Temozolomide + Depatuxizumab mafodotin + Placebo for ABT-414AbbViePhase 3

❌Steroid eye drops + Vasoconstrictor eye drops + Ophthalmic steroid ointment + Depatuxizumab mafodotin + TemozolomideAbbViePhase 3

🔄Cediranib + Cediranib + Lomustine Chemotherapy + Placebo CediranibAstraZenecaPhase 3

🔄Cilengitide + TemozolomideMerckPhase 3

🔄Temozolomide + Pembrolizumab + PlaceboMerckPhase 3

Hype Score Breakdown

Clinical

Activity

Company

Novelty

Community

Clinical Trials (17)

NCT ID	Phase	Status	Start	Completion	Indication
NCT01127594	Phase 1	Completed	Jul 1, 2010	Jun 1, 2014	Melanoma
NCT00638963	Phase 2	Terminated	Oct 2, 2008	Jun 30, 2010	Breast Neoplasm
NCT00686725	Approved	Completed	Jun 24, 2008	Sep 28, 2011	Glioblastoma
NCT00632203	Phase 2	Terminated	Mar 4, 2008	Jan 7, 2011	Carcinoma, Non-Small-Cell Lung
NCT00723827	Pre-clinical	Completed	Mar 1, 2008	Sep 1, 2011	Glioblastoma
NCT00626990	Phase 3	Active	Dec 1, 2007	Dec 1, 2029	Brain and Central Nervous System Tumors
NCT00687323	Phase 2	Completed	Jul 30, 2007	Dec 23, 2012	Leukemia, Acute Myeloid
NCT00725010	Pre-clinical	Completed	Apr 1, 2007	Apr 1, 2009	Glioblastoma
NCT00423150	Phase 2	Terminated	Jan 26, 2007	Jun 11, 2009	Colorectal Neoplasm
NCT00424554	Phase 2	Completed	Sep 26, 2006	Feb 16, 2011	Glioma
NCT00392171	Phase 2	Completed	Jun 9, 2006	Sep 15, 2009	Glioma
NCT00704808	Pre-clinical	Completed	May 1, 2006	Dec 1, 2008	Glioblastoma
NCT00684567	Phase 2	Completed	Sep 27, 2005	Oct 31, 2007	Glioblastoma
NCT00076856	Phase 2	Completed	Mar 31, 2004	Mar 31, 2006	Carcinoma, Non-Small-Cell Lung
NCT00783393	Phase 2	Completed	May 27, 2003	Jun 17, 2005	Astrocytoma
NCT00034697	Phase 2	Terminated	Jun 28, 2001	Jan 30, 2003	Metastases, Neoplasm
NCT00831545	Phase 2	Completed	Dec 1, 2000	Oct 20, 2006	Metastases of Central Nervous System

Competing Products

20 competing products in Glioblastoma

See all competitors

Product	Company	Stage	Hype Score
Temferon	Genenta Science	Phase 1/2	26
PLX3397 + Temozolomide	Daiichi Sankyo	Phase 1/2	32
PLX3397	Daiichi Sankyo	Phase 2	27
ASP8374 + cemiplimab	Astellas Pharma	Phase 1	29
Nimotuzumab + Temozolomide	Sun Pharmaceutical	Phase 2	35
Gliadel + Avastin + Temodar	Eisai	Phase 2	27
BCNU Wafer + Irinotecan + Bevacizumab	Eisai	Phase 1/2	24
KHK2455	Kyowa Kirin	Pre-clinical	26
olaratumab + ramucirumab	Eli Lilly	Phase 2	35
enzastaurin + temozolomide	Eli Lilly	Phase 1/2	32
enzastaurin + bevacizumab + Enzyme-inducing antiepileptic drugs (EIAED) + Non-enzyme inducing antiepileptic drugs (NEIAED)	Eli Lilly	Phase 2	35
Temozolomide + Neratinib + QBS10072S + Abemaciclib + CC-115	Eli Lilly	Phase 2	42
Abemaciclib	Eli Lilly	Phase 2	39
Enzastaurin 500 milligram (mg) Once Daily (QD) + Enzastaurin 250 mg Twice Daily (BID)	Eli Lilly	Phase 2	35
Abemaciclib + LY3214996	Eli Lilly	Phase 1	29
enzastaurin + lomustine	Eli Lilly	Phase 3	40
Galunisertib + Lomustine + Placebo	Eli Lilly	Phase 2	35
DSP-7888 Dosing Emulsion + Bevacizumab	Sumitomo Pharma	Phase 3	40
DSP-7888	Sumitomo Pharma	Phase 1/2	32
BBI608 + Temozolomide	Sumitomo Pharma	Phase 1/2	32