Tacrolimus (Tac) + Methotrexate (MTX) + Ruxolitinib (Rux) + Cyclophosphamide + Mycophenolate mofetil (MMF)

Phase 3Recruiting

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Interest: 44/100

Hype Score

Development Stage

✓

Pre-clinical

✓

Phase 1

✓

Phase 2

Phase 3

Approved

Indication / Disease

Graft-versus-host Disease (GVHD)

Conditions

Graft-versus-host Disease (GVHD)

Trial Timeline

Apr 2, 2025 → Jan 17, 2031

NCT ID

NCT06615050

About Tacrolimus (Tac) + Methotrexate (MTX) + Ruxolitinib (Rux) + Cyclophosphamide + Mycophenolate mofetil (MMF)

Tacrolimus (Tac) + Methotrexate (MTX) + Ruxolitinib (Rux) + Cyclophosphamide + Mycophenolate mofetil (MMF) is a phase 3 stage product being developed by Incyte for Graft-versus-host Disease (GVHD). The current trial status is recruiting. This product is registered under clinical trial identifier NCT06615050. Target conditions include Graft-versus-host Disease (GVHD).

What happened to similar drugs?

0 of 5 similar drugs in Graft-versus-host Disease (GVHD) were approved

Approved (0) Terminated (0) Active (5)

🔄INCA034176 + Best Available Therapy (BAT)IncytePhase 3

🔄INCA034176IncytePhase 3

🔄Itacitinib + Placebo + Prednisone + MethylprednisoloneIncytePhase 3

🔄INCA034176 + Placebo + CorticosteroidsIncytePhase 3

🔄Ruxolitinib + Extracorporeal photopheresis (ECP) + Low-dose methotrexate (MTX) + Mycophenolate mofetil (MMF) + mechanistic Target of Rapamycin (mTOR) inhibitors (everolimus or sirolimus) + Infliximab + Rituximab + Pentostatin + Imatinib + IbrutinibIncytePhase 3

Hype Score Breakdown

Clinical

Activity

Company

Novelty

Community

Clinical Trials (1)

NCT ID	Phase	Status	Start	Completion	Indication
NCT06615050	Phase 3	Recruiting	Apr 2, 2025	Jan 17, 2031	Graft-versus-host Disease (GVHD)

Competing Products

20 competing products in Graft-versus-host Disease (GVHD)

See all competitors

Product	Company	Stage	Hype Score
Alefacept	Astellas Pharma	Phase 2	27
EQ001 + EQ001 Placebo	Biocon	Phase 1/2	32
SHR0302	Jiangsu Hengrui Medicine	Phase 1	29
Prednisone + Jakavi(ruxolitinib) + Prednisone	Novartis	Phase 2	42
PredEver	Novartis	Phase 2	35
Lifitegrast 5% Ophthalmic Solution + Placebo	Novartis	Phase 1	29
LBH589 + Methylprednisolone	Novartis	Phase 2	27
Panobinostat (LBH589)	Novartis	Phase 1/2	32
Filgrastim	Amgen	Pre-clinical	18
AMG 592	Amgen	Phase 1	29
AMG 592	Amgen	Phase 1	29
BMS-986004 + Sirolimus + Tacrolimus	Bristol Myers Squibb	Phase 1	29
Belumosudil (KD025)	Sanofi	Phase 2	27
Belumosudil 200 mg QD + Belumosudil 200 mg BID + Belumosudil 400 mg QD	Sanofi	Phase 2	35
AAT + Placebo	CSL	Phase 2/3	42
Ruxolitinib + Methylprednisolone	Incyte	Phase 2	39
Itacitinib + Corticosteroids	Incyte	Phase 1/2	21
Ruxolitinib	Incyte	Pre-clinical	23
Itacitinib + Corticosteroid	Incyte	Phase 1	26
INCA034176	Incyte	Phase 1/2	36