PLF with NeoFuse + PLF with NeoFuse + PLF with NeoFuse

Phase 1/2Withdrawn

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Interest: 18/100

Hype Score

Development Stage

✓

Pre-clinical

Phase 1

Phase 2

Phase 3

Approved

Indication / Disease

Degenerative Disc Disease

Conditions

Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis

Trial Timeline

Nov 1, 2008 → Nov 1, 2011

NCT ID

NCT00810212

About PLF with NeoFuse + PLF with NeoFuse + PLF with NeoFuse

PLF with NeoFuse + PLF with NeoFuse + PLF with NeoFuse is a phase 1/2 stage product being developed by Mesoblast for Degenerative Disc Disease. The current trial status is withdrawn. This product is registered under clinical trial identifier NCT00810212. Target conditions include Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis.

What happened to similar drugs?

1 of 6 similar drugs in Degenerative Disc Disease were approved

Approved (1) Terminated (1) Active (4)

✅PimavanserinAcadia PharmaceuticalsApproved

❌LatozinemabAlectorPhase 3

🔄Pimavanserin + PlaceboAcadia PharmaceuticalsPhase 3

🔄PimavanserinAcadia PharmaceuticalsPhase 3

🔄Rexlemestrocel-L + HA mixture + SalineMesoblastPhase 3

🔄Rexlemestrocel-L + Rexlemestrocel-L + HA Mixture + PlaceboMesoblastPhase 3

Hype Score Breakdown

Clinical

Activity

Company

Novelty

Community

Clinical Trials (1)

NCT ID	Phase	Status	Start	Completion	Indication
NCT00810212	Phase 1/2	Withdrawn	Nov 1, 2008	Nov 1, 2011	Degenerative Disc Disease

Competing Products

17 competing products in Degenerative Disc Disease

See all competitors

Product	Company	Stage	Hype Score
Latozinemab	Alector	Phase 3	22
YH14618 + YH14618 + YH14618 + Placebo	Yuhan	Phase 1/2	32
Placebo + YH14618	Yuhan	Phase 2	35
Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells	Astellas Pharma	Phase 1/2	39
ONO-2808 + Placebo	Ono Pharmaceutical	Phase 1	29
Pimavanserin + Placebo	Acadia Pharmaceuticals	Phase 3	37
Pimavanserin	Acadia Pharmaceuticals	Approved	47
Pimavanserin	Acadia Pharmaceuticals	Phase 3	37
Lumbar Interbody Fusion with Autograft + Lumbar Interbody Fusion with NeoFuse + Lumbar Interbody Fusion with NeoFuse	Mesoblast	Phase 2	29
NeoFuse	Mesoblast	Phase 2	29
Rexlemestrocel-L + HA mixture + Saline	Mesoblast	Phase 3	41
Single Dose MPCs Injection + Single Dose MPCs Injection	Mesoblast	Phase 2	29
Rexlemestrocel-L + Rexlemestrocel-L + HA Mixture + Placebo	Mesoblast	Phase 3	34
NeoFuse	Mesoblast	Phase 1/2	26
NeoFuse	Mesoblast	Phase 1/2	26
Use iliac bone graft + use bone morphogenetic protein + use bone derived allograft MSCs + Use adipose tissue derived MSCs + Use amnion/placental derived MSCs	Brain Biotech	Phase 2/3	28
Blood sampling, skin biopsy, excreta sampling, lumbar puncture	Brain Biotech	Pre-clinical	23