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pembrolizumab + lenvatinib + regorafenib + TAS-102 (trifluridine and tipiracil)

Phase 3Completed
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Interest: 40/100
40
Hype Score

Development Stage

✓
Pre-clinical
✓
Phase 1
✓
Phase 2
4
Phase 3
5
Approved
Indication / Disease

Colorectal Neoplasms

Conditions

Colorectal Neoplasms

Trial Timeline

Mar 29, 2021 → Sep 27, 2024

NCT ID
NCT04776148

About pembrolizumab + lenvatinib + regorafenib + TAS-102 (trifluridine and tipiracil)

pembrolizumab + lenvatinib + regorafenib + TAS-102 (trifluridine and tipiracil) is a phase 3 stage product being developed by Eisai for Colorectal Neoplasms. The current trial status is completed. This product is registered under clinical trial identifier NCT04776148. Target conditions include Colorectal Neoplasms.

What happened to similar drugs?

15 of 20 similar drugs in Colorectal Neoplasms were approved

Approved (15) Terminated (3) Active (4)
✅Rocuronium IV bolus 0.1 mg/kg guided by TOF that must remain between 1-3 during surgery + Rocuronium IV bolus 0.1 mg/kg guided by TOF 0/4 and PTC≤ 2MerckApproved
✅Cetuximab (EGFR inhibitor) + Bevacizumab + Irinotecan (CPT-11) + Oxaliplatin + Leucovorin and 5-FU + CapecitabineMerckApproved
✅5-FU based doublet chemotherapy + bevacizumabRocheApproved
✅capecitabine [Xeloda]RocheApproved
✅5-Fluorouracil + Bevacizumab + Irinotecan + OxaliplatinRocheApproved
✅Oxaliplatin + Capecitabine + Bevacizumab + Leucovorin + 5-Fluouracil + IrinotecanRocheApproved
✅CapecitabineRocheApproved

Hype Score Breakdown

Clinical
17
Activity
8
Company
15
Novelty
0
Community
0

Clinical Trials (1)

NCT IDPhaseStatus
NCT04776148Phase 3Completed

Competing Products

20 competing products in Colorectal Neoplasms

See all competitors
ProductCompanyStageHype Score
Cetuximab + Oxaliplatin + CapecitabineEli LillyPhase 2
35
IMC-1121B (ramucirumab) + Oxaliplatin + Folinic acid + 5-FU + 5-FUEli LillyPhase 2
35
ZN-c3 + Encorafenib + CetuximabZentalis PharmaceuticalsPhase 1
11
ALIMTA + OxaliplatinEli LillyPhase 2
35
eFT508 + AvelumabeFFECTOR TherapeuticsPhase 2
25
Bevacizumab + Oxaliplatin + CapecitabineChugai PharmaceuticalPhase 1/2
32
Bevacizumab + 5-fluorouracil + Leucovorin calcium + Irinotecan hydrochloride + Oxaliplatin + CapecitabineChugai PharmaceuticalPhase 2
31
FOLFIRI + FOLFOX-4 + FOLFIRI-HD + FOLFOX-7 + FOLFIRINOXChugai PharmaceuticalPhase 2/3
38
Gemcitabine and UFTE chemotherapyYuhanPhase 2
35
CPT-11 and TS-1 + CPT-11, 5-FU and l-LVDaiichi SankyoPhase 2/3
38
CPT-11 based regimensDaiichi SankyoPre-clinical
26
CS7017 + irinotecan, leucovorin, and 5-fluorouracil (5-FU) (FOLFIRI)Daiichi SankyoPhase 2
35
Tivantinib + Placebo + Cetuximab + IrinotecanDaiichi SankyoPhase 1/2
32
DS-8201a 5.4 mg/kg Q3W + DS-8201a 6.4 mg/kg Q3WDaiichi SankyoPhase 2
35
Trastuzumab deruxtecanDaiichi SankyoPhase 2
39
CS-1008 + irinotecanDaiichi SankyoPhase 2
27
CS-7017 + PlaceboDaiichi SankyoPhase 2
27
Patritumab DeruxtecanDaiichi SankyoPhase 2
27
CS-1008 + FOLFIRIDaiichi SankyoPhase 1
29
DS-8273a + nivolumabDaiichi SankyoPhase 1
21