Pembrolizumab + Lenvatinib

Phase 2Active

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Interest: 39/100

Hype Score

Development Stage

✓

Pre-clinical

✓

Phase 1

Phase 2

Phase 3

Approved

Indication / Disease

Melanoma, Uveal

Conditions

Melanoma, Uveal

Trial Timeline

Aug 2, 2022 → Jun 1, 2027

NCT ID

NCT05308901

About Pembrolizumab + Lenvatinib

Pembrolizumab + Lenvatinib is a phase 2 stage product being developed by Eisai for Melanoma, Uveal. The current trial status is active. This product is registered under clinical trial identifier NCT05308901. Target conditions include Melanoma, Uveal.

What happened to similar drugs?

4 of 20 similar drugs in Melanoma, Uveal were approved

Approved (4) Terminated (2) Active (14)

✅dabrafenib + trametinibNovartisApproved

✅ZelborafRocheApproved

✅Nivolumab + RelatlimabBristol Myers SquibbApproved

✅Fibrin Sealant (Tisseel) used in the Experimental Arm.BaxterApproved

❌Tasisulam-sodium + PaclitaxelEli LillyPhase 3

🔄Pembrolizumab + Lenvatinib + Placebo for lenvatinibEisaiPhase 3

Hype Score Breakdown

Clinical

Activity

Company

Novelty

Community

Clinical Trials (4)

NCT ID	Phase	Status	Start	Completion	Indication
NCT05308901	Phase 2	Active	Aug 2, 2022	Jun 1, 2027	Melanoma, Uveal
NCT05064280	Phase 2	Recruiting	Jan 20, 2022	Feb 28, 2028	Brain Metastases
NCT04704219	Phase 2	Completed	Feb 23, 2021	Oct 21, 2025	Renal Cell Carcinoma
NCT03797326	Phase 2	Completed	Feb 12, 2019	Oct 28, 2024	Advanced Solid Tumors

Competing Products

20 competing products in Melanoma, Uveal

See all competitors

Product	Company	Stage	Hype Score
mRNA-4157 + Pembrolizumab	Merck	Phase 2	39
AVT32-DRL_PB + Keytruda	Dr. Reddy's Laboratories	Phase 1	33
Binimetinib Oral Tablet	Biotrial	Phase 1	15
Tasisulam-sodium + Paclitaxel	Eli Lilly	Phase 3	32
[203Pb]VMT01 + [212Pb]VMT01 + Nivolumab	Perspective Therapeutics	Phase 1/2	33
[203Pb]VMT01 + [68Ga]VMT02	Perspective Therapeutics	Phase 1	23
FYB206 + Keytruda	Formycon AG	Phase 1	23
PLX3397	Daiichi Sankyo	Pre-clinical	26
PLX3397 + Pembrolizumab	Daiichi Sankyo	Phase 1/2	24
Trastuzumab deruxtecan	Daiichi Sankyo	Phase 2	39
DS-8273a + Nivolumab	Daiichi Sankyo	Phase 1	29
PLX3397 + vemurafenib	Daiichi Sankyo	Phase 1	21
enfortumab vedotin + pembrolizumab	Astellas Pharma	Phase 2	42
CP-461	Astellas Pharma	Phase 2	27
YM155	Astellas Pharma	Phase 2	35
YM155 + Docetaxel	Astellas Pharma	Phase 2	35
Denileukin diftitox	Eisai	Phase 2	35
E7080	Eisai	Phase 1	29
lenvatinib + pembrolizumab	Eisai	Phase 2	35
MORAb-004 (monoclonal antibody)	Eisai	Phase 2	35