Pembrolizumab

Phase 2Withdrawn

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Interest: 27/100

Hype Score

Development Stage

✓

Pre-clinical

✓

Phase 1

Phase 2

Phase 3

Approved

Indication / Disease

Colon Cancer

Conditions

Colon Cancer

Trial Timeline

May 20, 2020 → Dec 1, 2022

NCT ID

NCT04231526

About Pembrolizumab

Pembrolizumab is a phase 2 stage product being developed by Merck for Colon Cancer. The current trial status is withdrawn. This product is registered under clinical trial identifier NCT04231526. Target conditions include Colon Cancer.

What happened to similar drugs?

4 of 14 similar drugs in Colon Cancer were approved

Approved (4) Terminated (5) Active (6)

🔄fospropofol disodiumEisaiPhase 3

🔄Calderasib + Oxaliplatin + Leucovorin/levofolinate calcium + 5-Fluorouracil + Cetuximab + Bevacizumab + Bevacizumab biosimilarMerckPhase 3

❌AvelumabMerckPhase 3

🔄Systemic treatmentRochePhase 3

❌AZLI + PlaceboGilead SciencesPhase 3

🔄Isovorin + UFTPfizerPhase 3

✅Methylnaltrexone Bromide (MNTX) + PlaceboPfizerApproved

Hype Score Breakdown

Clinical

Activity

Company

Novelty

Community

Clinical Trials (20)

NCT ID	Phase	Status	Start	Completion	Indication
NCT02083484	Pre-clinical	Completed	—	—	Melanoma
NCT07302347	Phase 1/2	Recruiting	Mar 31, 2026	Dec 31, 2029	Malignant Neoplasm
NCT07089992	Phase 2	Recruiting	Dec 4, 2025	Dec 1, 2028	Sarcoma
NCT07007273	Phase 2	Recruiting	Jun 20, 2025	Jul 1, 2030	Cutaneous Sarcoma
NCT04569461	Phase 2	Withdrawn	Jun 1, 2025	Dec 1, 2026	Prostate Cancer
NCT05815927	Phase 3	Recruiting	May 23, 2025	Mar 30, 2030	Oligometastatic Squamous Cell Carcinoma of the Head and Neck
NCT05852223	Phase 2	Recruiting	Dec 20, 2024	Dec 1, 2027	Differentiated Thyroid Cancer
NCT05879120	Phase 2	Withdrawn	Jul 30, 2024	Oct 2, 2024	Recurrent Glioblastoma
NCT06004336	Phase 2	Recruiting	Oct 31, 2023	Jan 1, 2029	Oligometastatic Renal Cell Carcinoma
NCT05496036	Phase 2	Recruiting	Feb 13, 2023	Sep 30, 2027	Merkel Cell Carcinoma
NCT05131919	Phase 2	Active	Dec 22, 2022	Jul 1, 2031	Colorectal Cancer
NCT05197322	Phase 2	Recruiting	Jul 20, 2022	Dec 1, 2028	Adenocarcinoma of the Colon
NCT05406713	Phase 2	Active	Jul 13, 2022	Jan 1, 2028	Muscle Invasive Bladder Carcinoma
NCT05025813	Phase 2	Recruiting	Jun 28, 2022	Jun 1, 2027	Cutaneous Squamous Cell Carcinoma of the Head and Neck
NCT06413095	Phase 1	Completed	Jun 1, 2022	Jun 22, 2023	Head and Neck Squamous Cell Carcinoma
NCT05191472	Phase 2	Terminated	May 3, 2022	Dec 31, 2023	Multiple Myeloma
NCT05204160	Phase 2	Withdrawn	Apr 11, 2022	Feb 27, 2024	Plasma Cell Myeloma
NCT04575961	Phase 2	Active	Feb 22, 2022	Mar 1, 2028	Ovarian Cancer
NCT04417166	Phase 2	Recruiting	Feb 11, 2022	Dec 1, 2026	Lymphoma, Extranodal NK-T-Cell
NCT05188508	Phase 2	Recruiting	Jan 14, 2022	Jan 1, 2027	Glioma

Competing Products

20 competing products in Colon Cancer

See all competitors

Product	Company	Stage	Hype Score
FOLFIRI + E7820	Eisai	Phase 1/2	24
fospropofol disodium	Eisai	Phase 3	40
AQUAVAN® (fospropofol disodium) Injection + Midazolam HCl	Eisai	Phase 2/3	38
fospropofol disodium	Eisai	Phase 2	27
fospropofol disodium	Eisai	Phase 2	35
Cetuximab + Irinotecan + IMC-A12 (cixutumumab)	Eli Lilly	Phase 2	27
Ramucirumab + Icrucumab + mFOLFOX-6	Eli Lilly	Phase 2	35
Vinorelbine Tartrate	Eli Lilly	Phase 2	35
Enzastaurin HCl	Eli Lilly	Phase 2	35
Remimazolam Tosilate for Injection	Jiangsu Hengrui Medicine	Pre-clinical	26
ULTRESA + PANCREAZE + CREON + ZENPEP + other non-sponsor pancreatic enzyme replacement therapy + PERTZYE	AbbVie	Pre-clinical	18
Vandetanib + Capecitabine + Oxaliplatin + Bevacizumab	AstraZeneca	Phase 1	29
AZD0292	AstraZeneca	Phase 2	42
Calderasib + Oxaliplatin + Leucovorin/levofolinate calcium + 5-Fluorouracil + Cetuximab + Bevacizumab + Bevacizumab biosimilar	Merck	Phase 3	47
Cetuximab	Merck	Phase 2	27
Entereg + Entereg + placebo	Merck	Phase 2	35
Pembrolizumab	Merck	Phase 2	42
Pembrolizumab + Ibrutinib	Merck	Phase 1/2	32
pembrolizumab + Poly-ICLC	Merck	Phase 1/2	32
MK-2206	Merck	Phase 2	27