methylnaltrexone + placebo

ApprovedWithdrawn

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Interest: 29/100

Hype Score

Development Stage

✓

Pre-clinical

✓

Phase 1

✓

Phase 2

✓

Phase 3

Approved

Indication / Disease

Opioid-Induced Constipation

Conditions

Opioid-Induced Constipation

Trial Timeline

Mar 1, 2009 → Aug 1, 2009

NCT ID

NCT00858754

About methylnaltrexone + placebo

methylnaltrexone + placebo is a approved stage product being developed by Bausch Health for Opioid-Induced Constipation. The current trial status is withdrawn. This product is registered under clinical trial identifier NCT00858754. Target conditions include Opioid-Induced Constipation.

What happened to similar drugs?

3 of 20 similar drugs in Opioid-Induced Constipation were approved

Approved (3) Terminated (7) Active (10)

✅Naldemedine + PlaceboShionogiApproved

✅Methylnaltrexone bromideBausch HealthApproved

✅Methylnaltrexone + PlaceboBausch HealthApproved

🔄Naldemedine + PlaceboShionogiPhase 3

❌NKTR-118 + NKTR-118 + PlaceboAstraZenecaPhase 3

Hype Score Breakdown

Clinical

Activity

Company

Novelty

Community

Clinical Trials (5)

NCT ID	Phase	Status	Start	Completion	Indication
NCT01186770	Phase 3	Completed	Sep 1, 2010	Sep 8, 2011	Opioid-Induced Constipation
NCT00936884	Phase 3	Completed	Jul 1, 2009	Nov 1, 2013	Constipation
NCT00858754	Approved	Withdrawn	Mar 1, 2009	Aug 1, 2009	Opioid-Induced Constipation
NCT00672477	Approved	Completed	Jun 1, 2008	Feb 1, 2013	Opioid-Induced Constipation
NCT01366365	Phase 1	Completed	Oct 1, 2006	Nov 1, 2006	Healthy Adults

Competing Products

20 competing products in Opioid-Induced Constipation

See all competitors

Product	Company	Stage	Hype Score
Naldemedine + Placebo	Shionogi	Phase 3	40
Naldemedine + Placebo	Shionogi	Approved	50
Naldemedine	Shionogi	Phase 1/2	39
Naldemedine + Placebo	Shionogi	Phase 3	40
Placebo + Naldemedine	Shionogi	Phase 2	35
Naldemedine + Placebo	Shionogi	Phase 3	40
Naloxegol	Kyowa Kirin	Pre-clinical	26
NKTR-118 + NKTR-118 + Placebo	AstraZeneca	Phase 3	32
NKTR-118 + Usual care	AstraZeneca	Phase 3	40
NKTR-118 + NKTR-118 + Placebo	AstraZeneca	Phase 3	40
NKTR-118 + NKTR-118 + Placebo	AstraZeneca	Phase 3	40
Naloxegol + Placebo Oral Capsule	AstraZeneca	Phase 2	27
NKTR-118 + NKTR-118 + Placebo	AstraZeneca	Phase 3	40
CB-5945 + Placebo	Merck	Phase 3	32
CB-5945 + Placebo	Merck	Phase 3	32
CB-5945 + Placebo	Merck	Phase 3	32
CB-5945 + Placebo	Merck	Phase 3	32
Tegaserod	Novartis	Phase 3	32
Tegaserod	Novartis	Phase 3	32
Methylnaltrexone bromide + Placebo	Pfizer	Phase 2	35