BiotechTube

MBG453 + NIS793 + Spartalizumab + Decitabine

Phase 1Withdrawn
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Interest: 21/100
21
Hype Score

Development Stage

✓
Pre-clinical
2
Phase 1
3
Phase 2
4
Phase 3
5
Approved
Indication / Disease

Primary Myelofibrosis

Conditions

Primary Myelofibrosis, Myelofibrosis, PMF, Post-Essential Thrombocythemia Myelofibrosis, Post-Polycythemia Vera Myelofibrosis

Trial Timeline

Nov 30, 2020 → Apr 11, 2024

NCT ID
NCT04283526

About MBG453 + NIS793 + Spartalizumab + Decitabine

MBG453 + NIS793 + Spartalizumab + Decitabine is a phase 1 stage product being developed by Novartis for Primary Myelofibrosis. The current trial status is withdrawn. This product is registered under clinical trial identifier NCT04283526. Target conditions include Primary Myelofibrosis, Myelofibrosis, PMF.

What happened to similar drugs?

20 of 20 similar drugs in Primary Myelofibrosis were approved

Approved (20) Terminated (6) Active (0)
✅Latanoprost plus adjunctive glaucoma medicationSight SciencesApproved
✅Bempedoic acid 180 mg tabletDaiichi SankyoApproved
✅Duloxetine + PlaceboEli LillyApproved
✅Eszopiclone + PlaceboSumitomo PharmaApproved
✅Eszopiclone + PlaceboSumitomo PharmaApproved
✅Quetiapine extended release tablet + PlaceboAstraZenecaApproved
✅RosuvastatinAstraZenecaApproved

Hype Score Breakdown

Clinical
6
Activity
0
Company
15
Novelty
0
Community
0

Clinical Trials (1)

NCT IDPhaseStatus
NCT04283526Phase 1Withdrawn

Competing Products

20 competing products in Primary Myelofibrosis

See all competitors
ProductCompanyStageHype Score
Unfractionated heparinSinopharmPre-clinical
33
azenosertibZentalis PharmaceuticalsPhase 2
32
Latanoprost plus adjunctive glaucoma medicationSight SciencesApproved
25
REN001OnKure TherapeuticsPhase 1
11
Mavodelpar + PlaceboOnKure TherapeuticsPhase 2
25
REN001OnKure TherapeuticsPhase 2/3
20
SBI-100 Ophthalmic Emulsion, 0.5% + SBI-100 Ophthalmic Emulsion, 1.0% + SBI-100 Ophthalmic Emulsion, PlaceboSkye BiosciencePhase 2
25
Rituximab + Methotrexate + Cytarabine InjectionCelltrionPhase 2
31
Rituximab, lenalidomideCelltrionPhase 2
42
ibandronic acid 0.5mg + RIS placebo + 1.0mg ibandronic acid + ibandronic acid placebo + 2.5mg RISChugai PharmaceuticalPhase 3
40
CS-3150Daiichi SankyoPre-clinical
26
Bempedoic acid + Ezetimibe + Rosuvastatin + AtorvastatinDaiichi SankyoPre-clinical
33
Bempedoic acid 180 mg tabletDaiichi SankyoApproved
43
Combination of bempedoic acid and ezetimibeDaiichi SankyoPre-clinical
33
DS-8201a + T-DM1Daiichi SankyoPhase 3
44
Bempedoic acid and/or its fixed dose combination with ezetimibeDaiichi SankyoPre-clinical
18
Roxadustat + PlaceboAstellas PharmaPhase 3
32
Enzalutamide + ExemestaneAstellas PharmaPhase 2
35
Bocidelpar + PlaceboAstellas PharmaPhase 2
27
Methotrexate + Ibrutinib + TemozolomideSun PharmaceuticalPhase 2
31