dabrafenib + trametinib

ApprovedActive
0 views this week 0 watching Active
Interest: 47/100
47
Hype Score

Development Stage

Pre-clinical
Phase 1
Phase 2
Phase 3
5
Approved
Indication / Disease

Diffuse Astrocytoma

Conditions

Diffuse Astrocytoma, Anaplastic Astrocytoma, Astrocytoma, Oligodendroglioma, Childhood, Anaplastic Oligodendroglioma, Glioblastoma, Pilocytic Astrocytoma, Giant Cell Astrocytoma, Pleomorphic Xanthoastrocytoma, Anaplastic Pleomorphic Xanthoastrocytoma, Angiocentric Glioma, Chordoid Glioma of Third Ventricle, Gangliocytoma, Ganglioglioma, Anaplastic Ganglioglioma, Dysplastic Gangliocytoma of Cerebrellum, Desmoplastic Infantile Astrocytoma and Ganglioglioma, Papillary Glioneuronal Tumor, Rosette-forming Glioneuronal Tumor, Central Neurocytoma, Extraventricular Neurocytoma, Cerebellar Liponeurocytoma, Neurofibromatosis Type 1

Trial Timeline

Nov 4, 2019 → Nov 6, 2026

About dabrafenib + trametinib

dabrafenib + trametinib is a approved stage product being developed by Novartis for Diffuse Astrocytoma. The current trial status is active. This product is registered under clinical trial identifier NCT03975829. Target conditions include Diffuse Astrocytoma, Anaplastic Astrocytoma, Astrocytoma.

Hype Score Breakdown

Clinical
20
Activity
12
Company
15
Novelty
0
Community
0

Clinical Trials (17)

NCT IDPhaseStatus
NCT07440290Phase 2/3Recruiting
NCT04961619Pre-clinicalCompleted
NCT04547946Pre-clinicalCompleted
NCT05171374Pre-clinicalUNKNOWN
NCT04666272Pre-clinicalActive
NCT04452877Phase 2Completed
NCT03975829ApprovedActive
NCT02672358Phase 2Withdrawn
NCT03551626Phase 3Completed
NCT02974803Phase 2Terminated
NCT03340506ApprovedRecruiting
NCT02367859Phase 2Completed
NCT03091257Phase 1Active
NCT02083354Phase 2Completed
NCT02034110Phase 2Completed
NCT02039947Phase 2Completed
NCT01336634Phase 2Completed

Competing Products

20 competing products in Diffuse Astrocytoma

See all competitors
ProductCompanyStageHype Score
IVA337 + PlaceboInventivaPhase 2
29
Gemcitabine-Oxaliplatin plus Rituximab (R-GEMOX)Eli LillyPhase 2
35
rituximabCelltrionPhase 1
21
YM155Astellas PharmaPhase 2
27
enzastaurin + gemcitabine + rituximab + oxaliplatinEli LillyPhase 2
35
Bendamustine 90 mg/m2 IV on Days 1-2, Cycles 1-6Johnson & JohnsonPhase 2
31
VELCADE + Rituximab + Cyclophosphamide + Doxorubicin + Prednisone + VincristineJohnson & JohnsonPhase 2
35
Epcoritamab + Rituximab + Lenalidomide + Oxaliplatin + GemcitabineAbbViePhase 3
47
ABBV-525AbbViePhase 1
36
rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone + rituximab and lenalidomide + rituximab and bendamustine + rituximab, cytarabine, dexamethasone, and oxaliplatin/carboplatin + gemcitabine and oxaliplatin + Epcoritamab + rituximab, cyclophosphamide, reduced dose of doxorubicin, vincristine, and prednisone + Lenalidomide + rituximab, ifosfamide, carboplatin, and etoposide phosphate + Epcoritamab + Epcoritamab + Epcoritamab + Epcoritamab + Epcoritamab + Epcoritamab + Epcoritamab + Rituximab and Lenalidomide + EpcoritamabAbbViePhase 1/2
36
Copanlisib + VenetoclaxAbbViePhase 1/2
36
Epcoritamab + Investigator's Choice ChemotherapyAbbViePhase 3
44
Epcoritamab + LenalidomideAbbViePhase 2
39
Venetoclax + SelinexorAbbViePhase 1
29
EpcoritamabAbbViePhase 1
36
Loncastuximab Tesirine and EpcoritamabAbbViePhase 2
42
Epcoritamab + Investigator's Choice ChemotherapyAbbViePhase 3
44
bendamustine + navitoclax + rituximabAbbViePhase 2
27
EpcoritamabAbbViePhase 2
39
Epcoritamab (monotherapy) + Epcoritamab + Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone + Gemcitabine and oxaliplatin + Epcoritamab (maintenance) + Rituximab and lenalidomideAbbViePhase 1/2
36