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Cyclophosphamide + IRX-2 + Nivolumab

Phase 1Withdrawn
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Interest: 21/100
21
Hype Score

Development Stage

✓
Pre-clinical
2
Phase 1
3
Phase 2
4
Phase 3
5
Approved
Indication / Disease

Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma

Conditions

Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma, Stage II Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7

Trial Timeline

Jul 1, 2020 → Jan 31, 2026

NCT ID
NCT03575234

About Cyclophosphamide + IRX-2 + Nivolumab

Cyclophosphamide + IRX-2 + Nivolumab is a phase 1 stage product being developed by Bristol Myers Squibb for Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma. The current trial status is withdrawn. This product is registered under clinical trial identifier NCT03575234. Target conditions include Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma, Stage II Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7.

What happened to similar drugs?

14 of 20 similar drugs in Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma were approved

Approved (14) Terminated (4) Active (6)
✅lopinavir/ritonavirAbbVieApproved
✅emtricitabine/tenofovir disoproxil fumarateMerckApproved
✅Human Papillomavirus 9-valent Vaccine, RecombinantMerckApproved
✅3-drug anti-HIV therapy + RaltegravirMerckApproved
✅GardasilMerckApproved
✅RaltegravirMerckApproved
✅RaltegravirMerckApproved

Hype Score Breakdown

Clinical
6
Activity
0
Company
15
Novelty
0
Community
0

Clinical Trials (1)

NCT IDPhaseStatus
NCT03575234Phase 1Withdrawn

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