Canakinumab

Phase 2Terminated

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Interest: 27/100

Hype Score

Development Stage

✓

Pre-clinical

✓

Phase 1

Phase 2

Phase 3

Approved

Indication / Disease

Mild Cognitive Impairment

Conditions

Mild Cognitive Impairment, Alzheimer Disease

Trial Timeline

Oct 28, 2021 → Mar 7, 2024

NCT ID

NCT04795466

About Canakinumab

Canakinumab is a phase 2 stage product being developed by Novartis for Mild Cognitive Impairment. The current trial status is terminated. This product is registered under clinical trial identifier NCT04795466. Target conditions include Mild Cognitive Impairment, Alzheimer Disease.

What happened to similar drugs?

8 of 17 similar drugs in Mild Cognitive Impairment were approved

Approved (8) Terminated (2) Active (8)

✅Aricept (donepezil hydrochloride) + placeboEisaiApproved

✅Donepezil HClEisaiApproved

✅ElagolixAbbVieApproved

✅Fluticasone propionate (Flovent Diskus) 250 mcg + budesonide 400 mcgAstraZenecaApproved

✅Aliskiren + Hydrochlorothiazide + AmlodipineNovartisApproved

✅Rivastigmine PatchNovartisApproved

✅ElidelBayerApproved

Hype Score Breakdown

Clinical

Activity

Company

Novelty

Community

Clinical Trials (19)

NCT ID	Phase	Status	Start	Completion	Indication
NCT04476706	Pre-clinical	Completed	—	—	Cytokine Release Syndrome in COVID-19-induced Pneumonia
NCT04795466	Phase 2	Terminated	Oct 28, 2021	Mar 7, 2024	Mild Cognitive Impairment
NCT04717635	Phase 3	Completed	Mar 30, 2021	Apr 16, 2025	Adult Onset Still's Disease
NCT04239157	Phase 2	Recruiting	Aug 25, 2020	Dec 31, 2026	Chronic Myelomonocytic Leukemia
NCT02980263	Phase 2	Withdrawn	Nov 15, 2016	Nov 30, 2017	Kawasaki Disease
NCT02756650	Phase 2	Completed	Jun 23, 2016	Jan 31, 2019	Behcet Disease
NCT02396212	Phase 3	Completed	May 7, 2015	Aug 1, 2018	Systemic Juvenile Idiopathic Arthritis
NCT02334748	Phase 3	Completed	Nov 3, 2014	Aug 31, 2018	Systemic Juvenile Idiopathic Arthritis
NCT01303380	Phase 2	Completed	Mar 1, 2011	Jul 1, 2014	Mevalonate Kinase Deficiency
NCT01276522	Phase 2	Completed	Jan 1, 2011	Dec 1, 2011	Schnitzler Syndrome
NCT01148797	Phase 2	Completed	Dec 1, 2010	—	Colchicine Resistant/Intolerant Familial Mediterranean Fever
NCT01170936	Phase 2	Completed	Jul 1, 2010	Dec 1, 2011	Urticaria
NCT01088880	Phase 2	Completed	Apr 1, 2010	Aug 1, 2011	Familial Mediterranean Fever
NCT00991146	Phase 3	Completed	Oct 1, 2009	Feb 1, 2012	Cryopyrin-associated Periodic Syndromes
NCT00891046	Phase 3	Completed	Sep 1, 2009	Dec 1, 2014	Systemic Juvenile Idiopathic Arthritis
NCT00927810	Phase 2	Completed	Jun 5, 2009	Aug 4, 2010	Gouty Arthritis
NCT00770601	Phase 3	Terminated	Jan 26, 2009	Feb 17, 2011	NOMID
NCT00554606	Phase 2	Completed	Oct 11, 2007	Aug 13, 2009	Rheumatoid Arthritis
NCT00487708	Phase 2	Completed	Jan 1, 2005	Jul 1, 2008	NALP3 Mutation

Competing Products

20 competing products in Mild Cognitive Impairment

See all competitors

Product	Company	Stage	Hype Score
Neurosteroid enantiomer	Oragenics	Phase 2	32
Ranirestat + Placebo	Eisai	Phase 2/3	38
Aricept (donepezil hydrochloride) + placebo	Eisai	Approved	43
Donepezil HCl	Eisai	Approved	43
Donanemab + Aducanumab	Eli Lilly	Phase 3	40
PPAR alpha + Hydrochlorothiazide + Placebo	Eli Lilly	Phase 2	35
Elagolix	AbbVie	Approved	35
AZD1446 + Placebo	AstraZeneca	Phase 2	35
MEDI1814 for IV injection + MEDI1814 for Subcutaneous Injection + IV Placebo + Placebo for Subcutaneous Injection	AstraZeneca	Phase 1	29
Fluticasone propionate (Flovent Diskus) 250 mcg + budesonide 400 mcg	AstraZeneca	Approved	43
AZD5213 + AZD5213 + AZD5213	AstraZeneca	Phase 2	35
budesonide/formoterol (Symbicort)	AstraZeneca	Phase 3	40
MK-8931	Merck	Phase 1	29
Montelukast to placebo + Placebo to montelukast	Merck	Pre-clinical	26
Verubecestat 12 mg (Parts 1 and 2) + Verubecestat 40 mg (Parts 1 and 2)	Merck	Phase 3	32
Aliskiren + Hydrochlorothiazide + Amlodipine	Novartis	Approved	43
LCZ696 + Sildenafil	Novartis	Phase 2	35
QCZ484 + Placebo	Novartis	Phase 1	29
Rivastigmine Patch	Novartis	Approved	43
AFQ056	Novartis	Phase 1	29