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Brexucabtagene Autoleucel (KTE-X19) + Fludarabine + Cyclophosphamide

Phase 1/2Active
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Interest: 36/100
36
Hype Score

Development Stage

✓
Pre-clinical
2
Phase 1
3
Phase 2
4
Phase 3
5
Approved
Indication / Disease

Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia

Conditions

Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia, Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma

Trial Timeline

Feb 1, 2016 → Feb 1, 2026

NCT ID
NCT02625480

About Brexucabtagene Autoleucel (KTE-X19) + Fludarabine + Cyclophosphamide

Brexucabtagene Autoleucel (KTE-X19) + Fludarabine + Cyclophosphamide is a phase 1/2 stage product being developed by Gilead Sciences for Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia. The current trial status is active. This product is registered under clinical trial identifier NCT02625480. Target conditions include Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia, Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma.

What happened to similar drugs?

0 of 10 similar drugs in Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia were approved

Approved (0) Terminated (1) Active (9)
🔄Tirabrutinib + Rituximab + TemozolomideOno PharmaceuticalPhase 3
🔄SHR2554; Chidamide analog tablets + SHR2554 analog tablets; ChidamideJiangsu Hengrui MedicinePhase 3
🔄Venetoclax + Bortezomib + Dexamethasone + Placebo for venetoclaxAbbViePhase 3
❌Blinatumomab + Standard of Care ChemotherapyAmgenPhase 3
🔄Axicabtagene Ciloleucel + Platinum-containing Salvage Chemotherapy + Cyclophosphamide + FludarabineGilead SciencesPhase 3
🔄Axicabtagene Ciloleucel + Cyclophosphamide + Fludarabine + Lenalidomide + Rituximab + Doxorubicin + Vincristine + Prednisone + BendamustineGilead SciencesPhase 3
🔄Odronextamab + Lenalidomide + RituximabRegeneron PharmaceuticalsPhase 3

Hype Score Breakdown

Clinical
9
Activity
12
Company
15
Novelty
0
Community
0

Clinical Trials (2)

NCT IDPhaseStatus
NCT04162756Pre-clinicalCompleted
NCT02625480Phase 1/2Active

Competing Products

20 competing products in Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia

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agenT-797MiNK TherapeuticsPhase 1
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Eribulin mesylateEisaiPhase 2
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Epcoritamab + Epcoritamab + rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone + Venetoclax + Epcoritamab + Lenalidomide + Epcoritamab + Pirtobrutinib + EpcoritamabEli LillyPhase 1/2
36
ISB 1342Glenmark PharmaceuticalsPhase 1
29
SHR2554; Chidamide analog tablets + SHR2554 analog tablets; ChidamideJiangsu Hengrui MedicinePhase 3
47
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39
Epcoritamab + Epcoritamab, lenalidomide and rituximabAbbViePhase 2
42
EtentamigAbbViePhase 1
33
Venetoclax + Bortezomib + Dexamethasone + Placebo for venetoclaxAbbViePhase 3
40
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33
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32
ABBV-453 + Dexamethasone + Daratumumab + LenalidomideAbbViePhase 1
33
AZD4573AstraZenecaPhase 2
35
Moxetumomab PasudotoxAstraZenecaPre-clinical
26