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ALN-AAT02 + Placebo + ALN-AAT02

Phase 1/2Terminated
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Interest: 21/100
21
Hype Score

Development Stage

✓
Pre-clinical
2
Phase 1
3
Phase 2
4
Phase 3
5
Approved
Indication / Disease

ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Conditions

ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Trial Timeline

Dec 5, 2018 → Jun 25, 2020

NCT ID
NCT03767829

About ALN-AAT02 + Placebo + ALN-AAT02

ALN-AAT02 + Placebo + ALN-AAT02 is a phase 1/2 stage product being developed by Alnylam Pharmaceuticals for ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease. The current trial status is terminated. This product is registered under clinical trial identifier NCT03767829. Target conditions include ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease.

What happened to similar drugs?

20 of 20 similar drugs in ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease were approved

Approved (20) Terminated (0) Active (0)
✅add-on pioglitazone + add-on sulphonylureaAMD BiotechApproved
✅Insulin Lispro Mix25 + Insulin Lispro Mix50Eli LillyApproved
✅Insulin Glargine + Insulin Lispro Premix (mid-mixture and low-mixture)Eli LillyApproved
✅exenatide and sitagliptin + exenatide and placeboEli LillyApproved
✅Tirzepatide + PlaceboEli LillyApproved
✅LisproEli LillyApproved
✅ToujeoMIRA PharmaceuticalsApproved

Hype Score Breakdown

Clinical
9
Activity
0
Company
12
Novelty
0
Community
0

Clinical Trials (1)

NCT IDPhaseStatus
NCT03767829Phase 1/2Terminated

Competing Products

20 competing products in ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

See all competitors
ProductCompanyStageHype Score
NEX-22A, a prolonged release formulation of liraglutideNanexa ABPhase 1
23
DRL-17822 or placeboDr. Reddy's LaboratoriesPhase 2
32
add-on pioglitazone + add-on sulphonylureaAMD BiotechApproved
29
MKP10241 + PlaceboMankind PharmaPhase 2
42
Daily injection of KBP/placebo for up to 28 daysEli LillyPhase 1
21
LY3209590 + Insulin DegludecEli LillyPhase 1
29
AC2993Eli LillyPhase 3
40
LY3209590 + PlaceboEli LillyPhase 1
29
Insulin Lispro Protamine Suspension + Insulin GlargineEli LillyPhase 3
40
LY2963016 + LantusEli LillyPhase 1
29
Empagliflozin + Other SGLT2 inhibitors + Other non-insulin GLDsEli LillyPre-clinical
26
Insulin Lispro Mix25 + Insulin Lispro Mix50Eli LillyApproved
43
Nasal Glucagon + Intramuscular GlucagonEli LillyPhase 3
40
Retatrutide + PlaceboEli LillyPhase 1
33
AG019 - Low Dose + Teplizumab + Placebo-AG019 + Placebo-Teplizumab + AG019 - High Dose + AG019 - High DosePrecigenPhase 1/2
26
LY4057996 SC + LY4057996 IV + Placebo SC + Placebo IV + Degludec SC + Lispro SC + Degludec IV + Pre-study basal insulin SCEli LillyPhase 1
36
Placebo + LinagliptinEli LillyPhase 3
40
Insulin Glargine + Insulin Lispro Premix (mid-mixture and low-mixture)Eli LillyApproved
43
teplizumab or placeboEli LillyPhase 1
21
LY2428757 + PlaceboEli LillyPhase 2
35