Alectinib + Vismodegib + Ipatasertib + Olaparib + Erlotinib + Bevacizumab + Vemurafenib + Cobimetinib + Trastuzumab Subcutaneous (SC) + Pertuzumab + Atezolizumab + Carboplatin + Paclitaxel + Cisplatin + Gemcitabine + Entrectinib + Ivosidenib + Pemigatinib

Phase 2Completed

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Interest: 35/100

Hype Score

Development Stage

✓

Pre-clinical

✓

Phase 1

Phase 2

Phase 3

Approved

Indication / Disease

Cancer of Unknown Primary Site

Conditions

Cancer of Unknown Primary Site

Trial Timeline

Jul 10, 2018 → Nov 7, 2024

NCT ID

NCT03498521

About Alectinib + Vismodegib + Ipatasertib + Olaparib + Erlotinib + Bevacizumab + Vemurafenib + Cobimetinib + Trastuzumab Subcutaneous (SC) + Pertuzumab + Atezolizumab + Carboplatin + Paclitaxel + Cisplatin + Gemcitabine + Entrectinib + Ivosidenib + Pemigatinib

Alectinib + Vismodegib + Ipatasertib + Olaparib + Erlotinib + Bevacizumab + Vemurafenib + Cobimetinib + Trastuzumab Subcutaneous (SC) + Pertuzumab + Atezolizumab + Carboplatin + Paclitaxel + Cisplatin + Gemcitabine + Entrectinib + Ivosidenib + Pemigatinib is a phase 2 stage product being developed by Roche for Cancer of Unknown Primary Site. The current trial status is completed. This product is registered under clinical trial identifier NCT03498521. Target conditions include Cancer of Unknown Primary Site.

What happened to similar drugs?

20 of 20 similar drugs in Cancer of Unknown Primary Site were approved

Approved (20) Terminated (4) Active (0)

✅arzoxifeneEli LillyApproved

✅EnzalutamideAstellas PharmaApproved

✅Enzalutamide + Androgen deprivation therapy (ADT)Astellas PharmaApproved

✅Enzalutamide + Abiraterone + Placebo for Enzalutamide + PrednisoneAstellas PharmaApproved

✅EnzalutamideAstellas PharmaApproved

✅Enzalutamide + FlutamideAstellas PharmaApproved

Hype Score Breakdown

Clinical

Activity

Company

Novelty

Community

Clinical Trials (1)

NCT ID	Phase	Status	Start	Completion	Indication
NCT03498521	Phase 2	Completed	Jul 10, 2018	Nov 7, 2024	Cancer of Unknown Primary Site

Competing Products

20 competing products in Cancer of Unknown Primary Site

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Product	Company	Stage	Hype Score
mFOLFOX regimen + Mitazalimab	Alligator Bioscience AB	Phase 2/3	35
Intratumoral Mitazalimab + Intratumoral Nivolumab	Alligator Bioscience AB	Phase 1	26
mRNA-2416	Moderna	Phase 2	0
Doxorubicin Hydrochloride Liposome Injection	Dr. Reddy's Laboratories	Phase 1	26
E7389	Eisai	Phase 1	29
Veliparib	AbbVie	Phase 2	27
AK-105	Akeso	Phase 1	29
XL820	Exelixis	Phase 1	26
Lymphoseek	Navidea Biopharmaceuticals	Phase 3	30
Lymphoseek	Navidea Biopharmaceuticals	Phase 3	30
ALT-P7 (HM2-MMAE)	Alteogen	Phase 1	29
pegylated liposomal doxorubicin (PLD) + PD-1	CSPC Pharmaceutical Group Limited	Phase 2	31
Biomarkers blood, urine and microbiota samples	Eli Lilly	Pre-clinical	30
gemcitabine + paclitaxel + bevacizumab	Eli Lilly	Phase 2	35
pemetrexed	Eli Lilly	Phase 2	27
LY3300054 + Prexasertib	Eli Lilly	Phase 1	29
BBP-398 with nivolumab	BridgeBio Pharma	Phase 1	18
Cetuximab + Oxaliplatin + Capecitabine	Eli Lilly	Phase 2	35
Necitumumab + Gemcitabine + Carboplatin	Eli Lilly	Phase 2	27
Gemcitabine + Adriamycine + Paclitaxel	Eli Lilly	Phase 2	35