| Divarasib + Pembrolizumab + Pemetrexed + Carboplatin + Cisplatin | Chugai Pharmaceutical | Phase 3 | Recruiting | |
| Datopotamab Deruxtecan + Rilvegostomig + Pembrolizumab | Daiichi Sankyo | Phase 3 | Recruiting | |
| Trastuzumab Deruxtecan + pembrolizumab + Pemetrexed + Chemotherapy | Daiichi Sankyo | Phase 3 | Recruiting | |
| Osimertinib + Datopotamab Deruxtecan | Daiichi Sankyo | Phase 3 | Recruiting | |
| Divarasib + Sotorasib + Adagrasib | Chugai Pharmaceutical | Phase 3 | Active | |
| Lazertinib 240 mg/160 mg + Gefitinib 250 mg + Lazertinib-matching placebo 240 mg/160 mg + Gefitinib-matching placebo 250 mg | Yuhan | Phase 3 | Active | |
| Datopotamab Deruxtecan + Rilvegostomig + Carboplatin + Cisplatin + Etoposide + Pemetrexed + Vinorelbine + UFT | Daiichi Sankyo | Phase 3 | Active | |
| DS-1062a + Docetaxel | Daiichi Sankyo | Phase 3 | Active | |
| Neoadjuvant lazertinib | Yuhan | Phase 2 | Recruiting | |
| Pembrolizumab + Carboplatin + Paclitaxel + Nab-paclitaxel + Pemetrexed + HER3-DXd | Daiichi Sankyo | Phase 2 | Recruiting | |
| Rilvegostomig + Ramucirumab + Dato-DXd | Daiichi Sankyo | Phase 2 | Recruiting | |
| Pemetrexed + Cisplatin + Placebo + Pemetrexed | Eli Lilly | Phase 3 | Completed | |
| pemetrexed + docetaxel | Eli Lilly | Phase 3 | Completed | |
| Erlotinib + Placebo | Astellas Pharma | Phase 3 | Completed | |
| Exisulind | Astellas Pharma | Phase 3 | Completed | |
| bexarotene with carboplatin and paclitaxel + carboplatin and paclitaxel | Eisai | Phase 3 | Completed | |
| bexarotene | Eisai | Phase 3 | Completed | |
| Pembrolizumab + Lenvatinib + Placebo for lenvatinib | Eisai | Phase 3 | Completed | |
| Pembrolizumab + Lenvatinib + Placebo for lenvatinib | Eisai | Phase 3 | Completed | |
| Nivolumab + Ipilimumab + Carboplatin + Cisplatin + Gemcitabine + Pemetrexed + Paclitaxel | Ono Pharmaceutical | Phase 3 | Completed | |
| ONO-4538 + Carboplatin + Paclitaxel + Bevacizumab + Placebo | Ono Pharmaceutical | Phase 3 | Completed | |
| Nivolumab + Cisplatin + Vinorelbine + Gemcitabine + Docetaxel + Pemetrexed + Carboplatin + Paclitaxel + Ipilimumab | Ono Pharmaceutical | Phase 3 | Completed | |
| TNG456 + abemaciclib | Eli Lilly | Phase 1/2 | Recruiting | |
| valemetostat tosylate + pembrolizumab | Daiichi Sankyo | Phase 1/2 | Recruiting | |
| PemCarbo + Pem only | Eli Lilly | Phase 3 | UNKNOWN | |
| pemetrexed + erlotinib | Eli Lilly | Phase 2 | Completed | |
| enzastaurin + pemetrexed + docetaxel + carboplatin | Eli Lilly | Phase 2 | Completed | |
| pemetrexed + gemcitabine | Eli Lilly | Phase 2 | Completed | |
| enzastaurin + placebo | Eli Lilly | Phase 2 | Completed | |
| pemetrexed + Best Supportive Care | Eli Lilly | Phase 2 | Completed | |
| Trastuzumab deruxtecan | Daiichi Sankyo | Phase 2 | Completed | |
| CS-1008 + Placebo + Paclitaxel + Carboplatin | Daiichi Sankyo | Phase 2 | Completed | |
| DS-1062a | Daiichi Sankyo | Phase 2 | Completed | |
| Erlotinib | Astellas Pharma | Phase 2 | Completed | |
| Tarceva (Trademark) (erlotinib HCl, OSI-774) + Combination carboplatin and paclitaxel | Astellas Pharma | Phase 2 | Completed | |
| eribulin mesylate + erlotinib + eribulin mesylate + erlotinib | Eisai | Phase 2 | Completed | |
| Lenvatinib + Lenvatinib matched placebo + BSC | Eisai | Phase 2 | Completed | |
| Nivolumab | Ono Pharmaceutical | Phase 2 | Completed | |
| ARQ 197 | Kyowa Kirin | Phase 2 | Completed | |
| RO7496353 + Atezolizumab + Capecitabine + S-1 + Nivolumab + Oxaliplatin + Nab-paclitaxel + Gemcitabine | Chugai Pharmaceutical | Phase 1 | Active | |
| ONO-4578 + ONO-4538 + Docetaxel + Ramucirumab | Ono Pharmaceutical | Phase 1 | Active | |
| S-3304 | Shionogi | Phase 1/2 | Completed | |
| eribulin mesylate + pemetrexed + Eribulin mesylate (eribulin; E7389) | Eisai | Phase 1/2 | Completed | |
| ARQ 197 and Erlotinib + Placebo and Erlotinib | Kyowa Kirin | Phase 3 | Terminated | |
| S-588410 + Placebo | Shionogi | Phase 2 | UNKNOWN | |
| Tomivosertib + Pembrolizumab + Pemetrexed | eFFECTOR Therapeutics | Phase 2 | Active | |
| YH25448 240mg | Yuhan | Phase 1 | Completed | |
| E7080 + E7080 + Paclitaxel + Carboplatin | Eisai | Phase 1 | Completed | |
| ARQ 197 and Erlotinib | Kyowa Kirin | Phase 1 | Completed | |
| mogamulizumab + Docetaxel | Kyowa Kirin | Phase 1 | Completed | |
| AC0010 | Sun Pharmaceutical | Phase 1/2 | UNKNOWN | |
| pemetrexed + cisplatin | Eli Lilly | Phase 2 | Terminated | |
| Datopotamab deruxtecan | Daiichi Sankyo | Phase 2 | Withdrawn | |
| Trastuzumab deruxtecan | Daiichi Sankyo | Phase 2 | Terminated | |
| Selpercatinib | Eli Lilly | Pre-clinical | Completed | |
| Pemetrexed | Eli Lilly | Pre-clinical | Completed | |
| Lazertinib + Platinum-based Chemotherapy | Yuhan | Pre-clinical | Completed | |
| CAB-AXL-ADC + PD-1 inhibitor | BioAtla | Phase 2 | Completed | |
| ASP8273 | Astellas Pharma | Phase 1/2 | Terminated | |
| Gilteritinib + Erlotinib | Astellas Pharma | Phase 1/2 | Terminated | |
| FYB206 + FYB206 + Keytruda | Formycon AG | Phase 3 | Terminated | |
| CAB-ROR2-ADC + PD-1 inhibitor | BioAtla | Phase 1/2 | Completed | |
| Lazertinib | Yuhan | Pre-clinical | UNKNOWN | |
| DS-1205c + Gefitinib | Daiichi Sankyo | Phase 1 | Terminated | |
| BBP-398 with nivolumab | BridgeBio Pharma | Phase 1 | Terminated | |