SPG Stimulation for BBB Modulation

About Realeve

Realeve is a private, clinical-stage medical device company pioneering a novel, externally powered neuromodulation platform. Its lead product, the Pulsante SPG microstimulation implant, is designed for minimally invasive surgical placement and is activated by a handheld external controller. While initially targeting the severe pain of cluster headaches with documented clinical use, the company is exploring broader CNS applications, including ischemic stroke and blood-brain barrier modulation. Founded in 2019 and based in Cleveland, Ohio, Realeve appears to be in a late-clinical or early commercial stage for its lead indication.

Therapeutic Areas