Palazestrant (OP-1250) + Ribociclib
ER+/HER2- Metastatic Breast Cancer (1st line combination)
Key Facts
About Olema Oncology
Olema Oncology is a clinical-stage biotech focused on transforming the treatment of endocrine-driven cancers, particularly metastatic ER+/HER2- breast cancer. Its core achievement is the development of palazestrant, an oral CERAN/SERD with a dual mechanism of action, now in two pivotal Phase 3 trials with top-line monotherapy data expected in fall 2026. The company's strategy leverages deep scientific expertise in nuclear receptors to address the critical unmet need of therapy resistance, aiming to establish palazestrant as a new standard of care. A second asset, OP-3136, a KAT6 inhibitor, represents a novel epigenetic approach currently in Phase 1.
View full company profileAbout Olema Oncology
Olema Oncology is a clinical-stage biotech focused on transforming the treatment of endocrine-driven cancers, particularly metastatic ER+/HER2- breast cancer. Its core achievement is the development of palazestrant, an oral CERAN/SERD with a dual mechanism of action, now in two pivotal Phase 3 trials with top-line monotherapy data expected in fall 2026. The company's strategy leverages deep scientific expertise in nuclear receptors to address the critical unmet need of therapy resistance, aiming to establish palazestrant as a new standard of care. A second asset, OP-3136, a KAT6 inhibitor, represents a novel epigenetic approach currently in Phase 1.
View full company profile