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LHP588

P. gingivalis-positive Alzheimer's Disease

Phase 2Active

Key Facts

Indication
P. gingivalis-positive Alzheimer's Disease
Phase
Phase 2
Status
Active
Company

About Lighthouse Pharmaceuticals

Lighthouse Pharmaceuticals is a private, clinical-stage biotech focused on precision therapeutics targeting infectious drivers of disease. The company's core platform develops selective protease inhibitors, with lead candidate LHP588 advancing in a Phase 2 trial for a genetically defined subset of Alzheimer's disease patients infected with P. gingivalis. Lighthouse has secured significant non-dilutive funding, including a $49.2M NIA grant, and has established a key animal health partnership, demonstrating validation of its approach. The company represents a high-risk, high-reward bet on the infectious etiology of neurodegeneration.

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