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GPR75 Program

Obesity

PreclinicalActive

Key Facts

Indication

Obesity

Phase

Preclinical

Status

Active

Company

Orion Biotechnology

About Orion Biotechnology

Orion Biotechnology is a preclinical-stage biotech company developing first-in-class GPCR-targeted therapies for obesity and metabolic diseases. Its core asset is the PROcisionX™ platform, which integrates phage display, multiplex chemical synthesis, and structure-activity analysis to generate optimized drug candidates in under six months. The company is advancing two lead candidates against the novel target GPR75 towards clinical development, led by a seasoned management team with deep pharmaceutical industry experience.

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Therapeutic Areas

Obesity Metabolic Disorders

Other Obesity Drugs

Drug	Company	Phase	Status
LET003	Harbour BioMed	Discovery	Active (Global)
LET001	Harbour BioMed	Discovery	Active (Global)
RGT-075	Regor Therapeutics	Phase 2b	Active
Anti‑Obesity Oral Drug	Premas Biotech	Phase 1	Active
Obesity Target Discovery Collaboration	Fauna Bio	Target Discovery/Preclinical	Active
GLP-1 variants	Heligenics	Discovery	Active
MYO Platform (Metabolic Disease)	Renbio	Pre-clinical	Active
Obesity Clinical Trials	IMA Clinical Research	Not Applicable (Service)	Active
KAYO-2000	KayoThera	Preclinical	Active
MVD-1 (SANA)	Eolo Pharma	Phase 1	Active
GIP-neutralizing antibody	Helicore Biopharma	Pre-clinical	Active
Antral Gastroplasty / Endoscopic Sleeve	Endo-TAGSS	Pre-clinical	Active