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GNSC-001

Osteoarthritis of the knee

Pre-clinicalActive

Key Facts

Indication
Osteoarthritis of the knee
Phase
Pre-clinical
Status
Active
Company

About Genascence

Genascence is a private, pre-revenue biotech focused on revolutionizing the treatment of osteoarthritis through gene therapy. Its lead program, GNSC-001, is a one-time intra-articular injection using an AAV vector to deliver the IL-1 receptor antagonist (IL-1Ra) gene, aiming to provide sustained inhibition of inflammation and cartilage destruction. The company was founded on technology licensed from Mayo Clinic and the University of Florida and is led by a team with deep experience in gene therapy development. Genascence is targeting one of the world's most common causes of chronic pain and disability, representing a massive market opportunity if successful.

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